摘要目的 研究不同衬底温度对氧化镧掺杂非晶碳薄膜中sp2/sp3的相对及率对其抗凝血性能的影响.方法 采用脉冲激光沉积方法,通过改变沉积时衬底的温度制备sp2/sp3不同比率的氧化镧掺杂非晶碳薄膜.利用扫描电子显微镜、拉曼光谱等材料表征方法,研究衬底温度对氧化镧掺杂非晶碳薄膜的微结构、形貌及亲水性的影响.利用血小板黏附实验观察血小板的黏附数量及形态.结果 成功制备sp2/sp3不同比率的氧化镧掺杂非晶碳薄膜.各非晶碳薄膜膜面光滑,呈网络状结构.随衬底温度从室温增加到400℃,非晶碳中的ID/IG比率逐渐从1.05增大到2.47;薄膜材料表面能变化较小但与纤维蛋白原的界面自由能从21.05 (dyn/cm)降低到9.76(dyn/cm).各样品血小板的聚集程度很小,呈球状,伪足较少,加热温度为300℃时沉积的样品抗凝血性能最优.结论 衬底温度能调控氧化镧掺杂非晶碳薄膜中sp2/sp3的相对比率,从而影响薄膜的表面自由能及界面自由能,进而影响薄膜的血液相容性能.

abstractsObjective To investigate the effects of different temperatureson the ratio of sp2 to sp3 in La2O3-doped amorphous carbon films and their haemocompatibility.Methods La2O3-doped amorphous carbon films with different ratios of sp2 to sp3 were prepared with varying temperatures of silicon-deposited substrate by using pulse laserd deposition.The effects of substrate temperatures on the microstmcture,surface morphology and hydrophilicity of La2O3 doped amorphous carbon films were studied using SEM and Raman spectra.The experiment of platelets adhesion was employed to observe the number and morphology of the adhering platelets.Results La2O3 doped amorphous carbon films with different ratios of sp2 to sp3 were successfully prepared.The surfaces of La2O3 doped amorphous carbon films were smooth and displayed a network structure.The ratio of ID/ IG in the film increased from 1.05 to 2.47 with the substrate temperature rising from room temperature to 400 ℃.Meanwhile,the surface energy of the film changed slightly,but the interfacial tension decreased gradually from 21.05 (dyn/cm) to 9.76 (dyn/cm).The platelet aggregation on all amorphous carbon films was mild,and the adhering platelets were spherical in size with less pseudopodia.The amorphous carbon film annealed at 300 ℃ exhibited optimal anticoagulant properties.Conclusions The ratio of sp2 to sp3 in La2O3 doped amorphous carbon films can be controlled by the substrate temperature,and in turn,influence the surface free energy and interfacial free energy,which is related to the haemocompatibility of La2O3 doped amorphous carbon films.