摘要探讨骨关节感染白细胞介素家族促炎因子与T辅助淋巴细胞1（Th1）/Th2的检测价值.研究发现，骨关节感染患者血清IL-6、IL-1β、IL-17与Th1、Th1/Th2呈负相关，与Th2呈正相关（ P<0.05）；治疗后血清IL-6、IL-1β、IL-17、Th2水平低于治疗前，有效患者低于无效患者，Th1、Th1/Th2水平高于治疗前，有效患者高于无效患者（ P<0.05）；血清IL-6、IL-1β、IL-17、外周血Th1、Th2、Th1/Th2治疗前后差值绝对值评估疗效的AUC分别为0.818、0.735、0.795、0.731、0.785、0.797.骨关节感染患者白细胞介素家族促炎因子与Th1/Th2失衡显著相关，可作为评估感染转归的重要辅助指标.

abstractsThe purpose of this study was to investigate the significance for detecting pro-inflammatory interleukin (IL) family cytokines, T helper lymphocytes (Th) 1 and 2 in osteoarticular infections. In these patients with osteoarticular infections, the study findings showed that the serum levels of IL-6, IL-1β and IL-17 were negatively correlated with the Th1 and Th1/Th2 levels, and were positively correlated with the Th2 level ( P<0.05) . After treatment, the serum levels of IL-6, IL-1β, IL-17, and Th2 were reduced from baseline, with even lower values of these indicators in patients who responded to treatment than those who did not; the Th1 and Th1/Th2 levels were increased from baseline, with even higher values of these indicators in patients who responded to treatment than those who did not ( P<0.05) . The absolute values of pre-post difference in serum levels of IL-6, IL-1β, and IL-17, peripheral Th1, Th2, and Th1/Th2 yielded areas under curve (AUCs) of 0.818, 0.735, 0.795, 0.731, 0.785, and 0.797, respectively, in treatment efficacy evaluation. In summary, the levels of pro-inflammatory interleukin family cytokines are significantly associated with the Th1/Th2 imbalance in patients with osteoarticular infections, and thus can be used as important adjuncts to assess the outcomes of infection.