摘要目的 观察小儿肾病综合征凝血系统功能紊乱情况.方法 检测26例肾病综合征患儿血浆凝血指标、D-二聚体(D-dimer)含量以及AT-Ⅲ活性,同时检测20例健康儿童作为正常对照.结果 (1) 肾病综合征发作期D-dimer含量为(0.91±0.36) mg/L,AT-Ⅲ活性为(57.6±19.8)%;缓解期分别为(0.32±0.10) mg/L,(75.4±21.1)%;正常对照组分别为(0.43±0.16) mg/L,(89.2±16.6)%.(2) 肾病综合征发作期较对照组D-dimer含量明显升高(P<0.01),AT-Ⅲ活性明显降低(P<0.01).(3) 肾病综合征合并高凝状态发生率为46%,DIC的发生率为8%.结论 肾病综合征患儿具有凝血、纤溶功能异常,DIC为其表现之一.

abstractsObjective To investigate the clotting system disfunction of nephrotic syndrome (NS).Methods The plasma clotting index,D-dimer concentration and antithrombin Ⅲ (AT-Ⅲ) activity of 26 children with NS were detected,in the meantime,20 healthy children served as control.Results (1) On onset of NS,the D-dimer was (0.91±0.36)mg/L,AT-Ⅲ was (57.6±19.8)%;in remission period,D-dimer was(0.32±0.10)mg/L,AT-Ⅲ was (75.4±21.1)%;the control group was (0.43±0.16)mg/L and (89.2±16.6)%,respectively.(2) D-dimer concentration of NS children in period of onset was obviously higher than that of control group (P<0.01),AT-Ⅲ was obviously lower than that of control group (P<0.01).(3) The incidence rate of hypercoagulability states was 46% and DIC was 8% in NS children.Conclusion The children who suffer from NS have the disfunction of blood clotting system and fibrolysis system.DIC is one of its manifestations.