摘要肝脏是实体肿瘤血行扩散最常见的部位,继发于实体器官肿瘤或血液系统恶性疾病引起的急性肝衰竭(ALF)虽不常见,但预后差、病死率高.肿瘤相关性ALF从症状开始发展到ALF的时间相对较快.恶性肿瘤是小儿急性肝衰竭( PALF)的病因之一,临床常见症状为黄疸、出血和肝性脑病.由于缺乏特异性临床表现,早期诊断困难.延迟诊断和治疗会导致预后不良.如何将原发性肿瘤的治疗与肝保护相结合,是临床医生面临的关键问题.肝移植是治疗PALF的有效方法.近年来,人工肝支持系统的发展为肝衰竭恢复提供了机会,并延长了肝移植的时间窗口.

abstractsLiver is the most common location for hematogenous spread of solid tumors. Clinically acute hepatic failure (ALF) secondary to either a solid organ tumor or a hematologic malignancy is rare,but with a poor prognosis and high mortality. The time between the onset of symptoms and ALF was relatively rapid. Malignancy is one of the causes of pediatric acute liver failure ( PALF). Common clinical symptoms were jaundice,haemorrhage,and hepatic encephalopathy. It is lack of specific clinical features and difficult to diagnose in early phase. Delayed diagnosis and treatment contribute to poor prognosis. How to combine the treatment of primary tumors and liver protection is critical issue to clinician. The effective therapy for patients with PALF is liver transplantation. In recent years,the development of artificial liver support is to provide a facilitating recovery chance and to prolong the window of opportunity for liver transplantation.