摘要重症药疹是临床上最常见的皮肤药物不良反应.免疫介导的不良反应是最常见的,包括轻度、自限性皮疹,IgE介导的超敏反应和严重的皮肤药物不良反应.严重的皮肤药物不良反应是一种罕见但可能危及生命的迟发性T细胞介导反应,疾病的范围从急性泛发性发疹性脓疱病到药疹伴嗜酸性粒细胞增多及系统症状,到最严重的疾病形式,Stevens‐Johnson综合征和中毒性表皮坏死松解症.药物所致的剥脱性皮炎可能是药疹伴嗜酸性粒细胞增多及系统症状的一个表现,患者典型的临床表现、用药病史、相关查体及相关辅助检查均有助于疾病的早期诊断.本文主要介绍急性泛发性发疹性脓疱病和剥脱性皮炎型药疹.

abstractsSevere drug eruption is the most common skin drug adverse reaction in clinic. Immune‐mediated adverse drug reactions occur commonly in clinical practice and include mild,self‐limited cutaneous eruptions, IgE‐mediated hypersensitivity, and severe cutaneous adverse drug reactions. Severe cutaneous adverse drug reactions represent an uncommon but potentially life‐threatening form of delayed T cell‐mediated reaction. The spectrum of illness ranges from acute generalized exanthematous pustulosis to drug reaction with eosinophilia with systemic symptoms,to the most severe form of illness,Stevens‐Johnson syndrome and toxic epidermal necrolysis. Drug‐induced exfoliative dermatitis may be one of the manifestations of eosinophilia with systemic symptoms. Typical clinical manifestations,medication history,relevant physical examinations and related auxiliary examinations of patients are helpful to the early diagnosis of the disease. This article introduced in detail the research progress of acute generalized eruptive pustulosis and exfoliative dermatitis eruption.