儿童食物依赖运动诱发严重过敏反应诊断和管理专家共识
Expert consensus on the diagnosis and management of food-dependent exercise-induced anaphylaxis in children
摘要食物依赖运动诱发严重过敏反应(FDEIA)是一种主要由IgE介导的特殊类型食物过敏,其特征为患儿在摄入特定过敏食物后,运动过程中出现全身系统性过敏反应,而单独进食或单独运动均不会诱发症状。该病起病急骤、症状严重,如不及时识别和处理,可迅速进展至多系统受累,甚至危及生命。多种食物可参与发病,其中小麦是最常见的食物诱因。目前,我国对FDEIA的系统性认识仍有限,临床实践中存在诊断不足与管理不规范等问题。为此,基于国内外最新诊治指南和我国相关研究证据,并结合我国临床实际,围绕FDEIA诊断、治疗、预防和管理,制定了该专家共识,旨在为临床提供规范化诊疗与管理指导。
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abstractsFood-dependent exercise-induced anaphylaxis(FDEIA)is a specific IgE-mediated allergic disorder characterized by systemic reactions triggered by physical exercise following the ingestion of a specific food allergen.Symptoms do not occur when the food is consumed without subsequent exercise,nor do they arise from exercise alone.The condition manifests abruptly with severe symptoms and,if not promptly recognized and managed,can rapidly progress to multisystem involvement and potentially life-threatening anaphylaxis.While various foods may serve as triggers,wheat is the most commonly implicated.In China,the systematic understanding of FDEIA remains limited,with underdiagnosis and inconsistent management being common in clinical practice.Based on the latest national and international guidelines,relevant Chinese research,and local clinical realities,this consensus proposed nine recommendations regarding the diagnosis,treatment,prevention,and overall management of FDEIA,aiming to provide standardized guidance for clinical practice.
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