首页>信号转导与靶向治疗(英文)>LncRNA MIAT impairs cardiac contractile function by acting on mitochondrial translocator protein TSPO in a mouse model of myocardial infarction
LncRNA MIAT impairs cardiac contractile function by acting on mitochondrial translocator protein TSPO in a mouse model of myocardial infarction
摘要Dear Editor,Long non-coding RNA MIAT(IncR-MIAT)has recently been identified as a risk factor for myocardial infarction(MI).1 However,how IncR-MIAT controls Ml remained yet to be determined.To shed light on this issue,we firstly detected the expression of IncR-MIAT using qRT-PCR and found a robust elevation(>5-fold)of IncR-MIAT level in heart of Ml mice relative to sham-operated control counterparts(Supplementary Fig.S1a).
作者单位Department of Pharmacology(State-Province Key Laboratories of Biomedicine-Pharmaceutics of China and Key Laboratory of Cardiovascular Medicine Research,Ministry of Education),College of Pharmacy,Harbin Medical University,Harbin,Heilongjiang,P.R.China[1]Department of Pharmacology(State-Province Key Laboratories of Biomedicine-Pharmaceutics of China and Key Laboratory of Cardiovascular Medicine Research,Ministry of Education),College of Pharmacy,Harbin Medical University,Harbin,Heilongjiang,P.R.China;Institute of Metabolic Disease,Heilongjiang Academy of Medical Science,Harbin,China[2]