换一批Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)
摘要There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations.In this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May 2021.The primary endpoint was progression-free survival(PFS)according to modified RECIST.The secondary outcomes included overall survival(OS),objective response rate(ORR),and safety.We performed propensity score matching approaches to reduce bias between two groups.After matching,228 pairs were included with a predominantly advanced disease population.Median PFS in combination group was 9.5 months(95％confidence interval[CI],8.4-11.0)versus 8.0 months(95％Cl,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1％vs.32.0％;P＜0.001).Grade 3/4 adverse events were observed at a rate of 15.8％and 7.5％in combination and monotherapy groups,respectively.Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.
更多相关知识
作者
Hai-Dong Zhu
[1]
Hai-Liang Li
[2]
Ming-Sheng Huang
[3]
Wei-Zhu Yang
[4]
Guo-Wen Yin
[5]
Bin-Yan Zhong
[6]
Jun-Hui Sun
[7]
Zhi-Cheng Jin
[1]
Jian-Jian Chen
[1]
Nai-Jian Ge
[8]
Wen-Bin Ding
[9]
Wen-Hui Li
[10]
Jin-Hua Huang
[11]
Wei Mu
[12]
Shan-Zhi Gu
[13]
Jia-Ping Li
[14]
Hui Zhao
[15]
Shu-Wei Wen
[16]
Yan-Ming Lei
[17]
Yu-Sheng Song
[18]
Chun-Wang Yuan
[19]
Wei-Dong Wang
[20]
Ming Huang
[21]
Wei Zhao
[22]
Jian-Bing Wu
[23]
Song Wang
[24]
Xu Zhu
[25]
Jian-Jun Han
[26]
Wei-Xin Ren
[27]
Zai-Ming Lu
[28]
Wen-Ge Xing
[29]
Yong Fan
[30]
Hai-Lan Lin
[31]
Zi-Shu Zhang
[32]
Guo-Hui Xu
[33]
Wen-Hao Hu
[34]
Qiang Tu
[35]
Hong-Ying Su
[36]
Chuan-Sheng Zheng
[37]
Yong Chen
[38]
Xu-Ya Zhao
[39]
Zhu-Ting Fang
[40]
Qi Wang
[41]
Jin-Wei Zhao
[42]
Ai-Bing Xu
[43]
Jian Xu
[44]
Qing-Hua Wu
[45]
Huan-Zhang Niu
[46]
Jian Wang
[47]
Feng Dai
[48]
Dui-Ping Feng
[49]
Qing-Dong Li
[50]
Rong-Shu Shi
[51]
Jia-Rui Li
[52]
Guang Yang
[53]
Hai-Bin Shi
[54]
Jian-Song Ji
[55]
Yu-E Liu
[56]
Zheng Cai
[57]
Po Yang
[58]
Yang Zhao
[59]
Xiao-Li Zhu
[6]
Li-Gong Lu
[60]
Gao-Jun Teng
[1]
学术成果认领
作者单位
Center of Interventional Radiology & Vascular Surgery,Department of Radiology,Zhongda Hospital,Medical School,Southeast University,Nanjing 210009,China
[1]
Department of Minimally invasive Intervention,The Affiliated Cancer Hospital of Zhengzhou University,Zhengzhou 450008,China
[2]
Department of Interventional Radiology,the Third Affiliated Hospital,Sun Yat-Sen University,Guangzhou 510630,China
[3]
Department of Interventional Radiology,Union Hospital of Fujian Medical University,Fuzhou 350001,China
[4]
Department of Interventional Radiology,Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University,Nanjing 210009,China
[5]
Department of Interventional Radiology,The First Affiliated Hospital of Soochow University,Soochow University,Suzhou 215006,China
[6]
Hepatobiliary and Pancreatic Interventional Treatment Center,Division of Hepatobiliary and Pancreatic Surgery,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China
[7]
Department of Interventional Radiology,Eastern Hospital of Hepatobiliary Surgery,Navy Medical University(Second Military Medical University),Shanghai 200438,China
[8]
Department of Interventional Radiology,Nantong First People's Hospital,Nantong 226001,China
[9]
Department of Interventional Radiology,Yancheng Third People's Hospital,Yancheng 224008,China
[10]
Department of Minimally Invasive Interventional Therapy,Sun Yat-Sen University Cancer Center,Guangzhou 510060,China
[11]
Department of Vascular Surgery,Southwest Hospital,Third Military Medical University(Army Medical University),Chongqing 400038,China
[12]
Department of Interventional Radiology,Hunan Cancer Hospital,Changsha 410031,China
[13]
Department of Interventional Oncology,The First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China
[14]
Department of Interventional Radiology,The Hospital of Nantong University,Nantong 226001,China
[15]
Department of Interventional Therapy,Shanxi Tumor Hospital,Taiyuan 030001,China
[16]
Department of Interventional Radiology,Tibet Autonomous Region People's Hospital,Lhasa 850000,China
[17]
Department of Interventional Radiology,Ganzhou People's Hospital,Ganzhou 341000,China
[18]
Center of Interventional Oncology and Liver Diseases,Beijing Youan Hospital,Capital Medical University,Beijing 100069,China
[19]
Department of Interventional Radiology,The Affiliated Wuxi People's Hospital of Nanjing Medical University,Wuxi 214023,China
[20]
Department of Minimally Invasive Interventional Therapy,Yunnan Tumor Hospital,The Third Affiliated Hospital of Kunming Medical University,Kunming 650118,China
[21]
Department of Radiology,First Affiliated Hospital of Kunming Medical University,Kunming 650032,China
[22]
Department of Oncology,The Second Affiliated Hospital of Nanchang University,Nanchang 330006,China
[23]
Department of Interventional Radiology,Affiliated Hospital of Qingdao University,Qingdao 266000,China
[24]
Department of Interventional Therapy,Peking University Cancer Hospital and Institute,Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education),Beijing 100142,China
[25]
Department of Interventional Radiology,Affiliated Cancer Hospital of Shandong First Medical University,Jinan 250117,China
[26]
interventional Therapy Center,The first Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China
[27]
Department of Radiology,Shengjing Hospital of China Medical University,Shenyang 830011,China
[28]
Department of Interventional Oncology,Tianjin Medical University Cancer Hospital,Tianjin 300060,China
[29]
Department of Radiology,Tianjin Medical University General Hospital,Tianjin 300052,China
[30]
Department of Tumor Interventional Therapy,Fujian Cancer Hospital,Fuzhou 350014,China
[31]
Department of Radiology,The Second Xiangya Hospital,Changsha 410011,China
[32]
Department of Interventional Radiology,Sichuan Cancer Hospital and Institute,Chengdu 610041,China
[33]
Department of Interventional Radiology,First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China
[34]
Department of Hepatobiliary Oncology Surgery,Department of Interventional Oncology,Jiangxi Cancer Hospital of Nanchang University,Nanchang 330029,China
[35]
Department of Interventional Radiology,The First Hospital of China Medical University,Shenyang 110001,China
[36]
Department of Radiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 110001,China
[37]
Department of Interventional Radiology,General hospital of Ningxia Medical University,Yinchuan 110001,China
[38]
Department of Interventional Radiology,Guizhou Cancer Hospital,Guiyang 550000,China
[39]
Department of Interventional Radiology,Fujian Provincial Hospital,Shengli Clinical Medical College of Fujian Medical University,Fuzhou 350001,China
[40]
Department of Interventional Radiology,Third Affiliated Hospital of Soochow University,Changzhou First Hospital,Changzhou 213004,China
[41]
Department of Interventional and Vascular Surgery,The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University,Changzhou 213003,China
[42]
Department of Interventional Therapy,Nantong Tumor Hospital,Nantong 226006,China
[43]
Department of Interventional Therapy,Jinling Hospital,School of Medicine,Nanjing University,Nanjing 210002,China
[44]
Department of Interventional Radiology,Affiliated Hospital of Jiangnan University,Wuxi 214122,China
[45]
Department of Interventional Radiology,The First Affiliated Hospital,and College of Clinical Medicine of Henan University of Science and Technology,Luoyang 471003,China
[46]
Department of Interventional Radiology and Vascular Surgery,Peking University First Hospital,Beijing 100034,China
[47]
Department of Interventional Radiology,The Second Hospital of Nanjing,Nanjing 210000,China
[48]
Department of Oncology and Vascular Intervention,First Hospital of Shanxi Medical University,Taiyuan 030001,China
[49]
Vascular and Interventional Department,Chongqing University Cancer Hospital,Chongqing 400000,China
[50]
Department of Interventional Radiology,The Affiliated Hospital of Zunyi Medical College,Zunyi 563000,China
[51]
Department of Interventional Therapy,The First Hospital of Jilin University,Changchun 130000,China
[52]
Department of Radiology,The Fourth Hospital of Hebei Medical University,Shijiazhuang,China
[53]
Department of Interventional Radiology,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China
[54]
Department of Radiology,Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research,School of Medicine,Lishui Hospital of Zhejiang University,Lishui 323000,China
[55]
Department of Interventional Radiology,Shanxi Provincial People's Hospital,Taiyuan 030012,China
[56]
Department of Interventional Medicine,The Second Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China
[57]
Department of Interventional & Vascular Surgery,The Fourth Hospital of Harbin Medical University,Harbin 150001,China
[58]
Department of Biostatistics,Nanjing Medical University,Nanjing 211166,China
[59]
Zhuhai Interventional Medical Center,Zhuhai Precision Medical Center,Zhuhai People's Hospital,Zhuhai Hospital Affiliated with Jinan University,Jinan University,Zhuhai 519000,China
[60]
栏目名称
DOI
10.1038/s41392-022-01235-0
发布时间
2024-03-15（万方平台首次上网日期，不代表论文的发表时间）
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