Promotion of liquid-to-solid phase transition of cGAS by Baicalein suppresses lung tumorigenesis

导出学术成果认领

摘要Dear Editor,Kras and p53 mutation are among the most common gene mutations in lung cancer,which has both the highest incidence and mortality rate among cancers.1 Kras/p53 mutation also causes mitochondrial dysfunction,which has been implicated to promote the inflammation-to-cancer transition.2

作者 Tiansheng Zheng ^[1] Haipeng Liu ^[2] Yifan Hong ^[3] Yajuan Cao ^[2] Qing Xia ^[4] Chengge Qin ^[5] Ming Li ^[6] Russel J.Reiter ^[7] Yidong Bai ^[7] Lihong Fan ^[4] 学术成果认领

作者单位 Department of Respiratory Medicine,Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai 200072,China;Department of Integrated Traditional Chinese & Western Medicine,Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai 200072,China ^[1] Clinical Translational Research Center,Shanghai Pulmonary Hospital,Tongji University School of Medicine,Shanghai 200433,China ^[2] Institute of Energy Metabolism and Health,Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai 200072,China;Institute of Molecular Physiology,Institue of Cancer Research,Shenzhen Bay Laboratory,Shenzhen 518132,China ^[3] Department of Respiratory Medicine,Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai 200072,China;Department of Integrated Traditional Chinese & Western Medicine,Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai 200072,China;Institute of Energy Metabolism and Health,Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai 200072,China ^[4] Institute of Energy Metabolism and Health,Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai 200072,China;Medical School of Nantong University,Nantong,Jiangsu 22601,China ^[5] Department of Integrated Traditional Chinese & Western Medicine,Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai 200072,China;Institute of Energy Metabolism and Health,Shanghai Tenth People's Hospital,Tongji University School of Medicine,Shanghai 200072,China ^[6] Department of Cell Systems and Anatomy,University of Texas Health San Antonio,San Antonio,Texas 78229,USA ^[7]

栏目名称 LETTERS

DOI 10.1038/s41392-023-01326-6

发布时间 2024-03-15