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Sebaceous gland reprogramming with a single gene,PPARG,and small molecules

摘要Dear Editor,Sebaceous glands(SG)contribute to 90％of the skin surface lipid production and play critical roles in regulating proper skin functions including epidermal barrier maintenance,dermal immune responses,and global body anti-microbial activities.1 Reduced sebaceous lipid has been implicated in diverse skin diseases,including scarring alopecia,inflammation,chronic itch,as well as premature aging of the skin.2 Especially,scar repair after deep burns or large-scale skin defect often leads to irreversible loss of appendages.

作者 Yiqiong Liu ^[1] Shuaifei Ji ^[1] Huanhuan Gao ^[1] Huating Chen ^[1] Jiangbing Xiang ^[1] Shaoyuan Cui ^[2] Christos C.Zouboulis ^[3] Aizhen Cai ^[4] Xiaobing Fu ^[1] Xiaoyan Sun ^[1] 学术成果认领

作者单位 Research Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Department and 4th Medical Center,PLA General Hospital and PLA Medical College;PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury,Repair,and Regeneration;Research Unit of Trauma Care,Tissue Repair and Regeneration,Chinese Academy of Medical Sciences,2019RU051,100048 Beijing,P.R.China ^[1] Department of Nephrology,The First Medical Center,Chinese PLA General Hospital,State Key Laboratory of Kidney Diseases,100048 Beijing,China ^[2] Departments of Dermatology,Venereology,Allergology,and Immunology,Staedtisches Klinikum Dessau,Brandenburg Medical School Theodor Fontane and Faculty of Health Sciences Brandenburg,Dessau,Germany ^[3] Institute of General Surgery,Department of General Surgery,the 1st Medical Center,PLA General Hospital,28 Fu Xing Road,100853 Beijing,P.R.China ^[4]

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DOI 10.1038/s41392-023-01531-3

发布时间 2024-03-15（万方平台首次上网日期，不代表论文的发表时间）