摘要胰腺癌是一种恶性程度极高的消化系统肿瘤,被称为“癌中之王”,其发病率在全世界范围内呈逐年上升趋势.目前,胰腺癌仍然缺乏有效的筛查方法,早期症状不明显,大多数胰腺癌确诊时已属于晚期,失去了手术的最佳时机,且其对放化疗及靶向治疗效果有限,预后极差.胰腺癌的发生、发展与遗传背景、环境因素、基础疾病及生活习惯密切相关,至今虽然已确定吸烟、肥胖、酒精、慢性胰腺炎、2型糖尿病及家族史等危险因素,但其病因仍不明确.近年来,越来越多研究结果显示:消化系统微生态失调与胰腺癌的病程演进存在联系.笔者就消化系统微生态与胰腺癌的研究现状与发展进行综述,旨在进一步认识消化系统微生态失调在胰腺癌发生、发展中的作用,为有效改善胰腺癌预后提供新途径.

abstractsPancreatic cancer is a highly malignant tumor of the digestive system,also known as "the king of cancer".Its incidence is increasing year by year worldwide.At present,there is still a lack of effective screening methods for pancreatic cancer,and the early symptoms are not obvious.Most pancreatic cancer is diagnosed in the late stage,and the best time for surgery has been lost,and patients often have poor response to radiotherapy,chemotherapy and targeted therapy,so the prognosis is very poor.The occurrence and development of pancreatic cancer are closely related to genetic background,environmental factors,basic diseases and living habits.So far,although certain risk factors have been identified,such as smoking,obesity,alcohol,chronic pancreatitis,type 2 diabetes mellitus,and family history,the cause of pancreatic cancer is still not very clear.In recent years,more and more studies have shown that in addition to the already recognized risk factors for pancreatic cancer,there is a certain relationship between digestive microecological disorders and the progression of pancreatic cancer.The authors review the research status of digestive system microecology and pancreatic cancer,in order to understand the role of digestive system microecology disorders in the occurrence and development of pancreatic cancer,thus providing a new way to effectively improve the prognosis of pancreatic cancer.