摘要The concept of foetal programming (FP) originated from human epidemiological studies,where foetal life nutrition was linked to health and disease status later in life.Since the proposal of this phenomenon,it has been evaluated in various animal models to gain further insights into the mechanisms underlying the foetal origins of health and disease in humans.In FP research,the sheep has been quite extensively used as a model for humans.In this paper we will review findings mainly from our Copenhagen sheep model,on the implications of late gestation malnutrition for growth,development,and metabolic and endocrine functions later in life,and discuss how these implications may depend on the diet fed to the animal in early postnatal life.Our results have indicated that negative implications of foetal malnutrition,both as a result of overnutrition and,particularly,late gestation undernutrition,can impair a wide range of endocrine functions regulating growth and presumably also reproductive traits.These implications are not readily observable early in postnatal life,but are increasingly manifested as the animal approaches adulthood.No intervention or cure is known that can reverse this programming in postnatal life.Our findings suggest that close to normal growth and slaughter results can be obtained at least until puberty in animals which have undergone adverse programming in foetal life,but manifestation of programming effects becomes increasingly evident in adult animals.Due to the risk of transfer of the adverse programming effects to future generations,it is therefore recommended that animals that are suspected to have undergone adverse FP are not used for reproduction.Unfortunately,no reliable biomarkers have as yet been identified that allow accurate identification of adversely programmed offspring at birth,except for very low or high birth weights,and,in pigs,characteristic changes in head shape (dolphin head).Future efforts should be therefore dedicated to identify reliable biomarkers and evaluate their effectiveness for alleviation/reversal of the adverse programming in postnatal life.Our sheep studies have shown that the adverse impacts of an extreme,high-fat diet in early postnatal life,but not prenatal undernutrition,can be largely reversed by dietary correction later in life.Thus,birth (at term) appears to be a critical set point for permanent programming in animals born precocial,such as sheep.Appropriate attention to the nutrition of the late pregnant dam should therefore be a priority in animal production systems.