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Gut microbiota and metabolites in lipid metabolism and intramuscular fat deposition:mechanisms and implications for meat quality

摘要Intramuscular fat(IMF)content serves as the key determinants of meat quality.Emerging evidence indicates that gut microbiota and their metabolites significantly influence IMF deposition levels by modulating host lipid metabo-lism through multiple pathways,positioning microbial regulation as a pivotal target for meat quality improvement.However,existing studies remain fragmented,predominantly focusing on isolated mechanisms or correlations without a systematic view of the regulatory network.This review consolidates the core mechanisms through which microbiota-derived metabolites including short-chain fatty acids,bile acids,branched-chain amino acids,trimeth-ylamine N-oxide,tryptophan derivatives,succinate,polyamines etc.,regulate IMF deposition and proposes a tar-geted intervention framework,the"gut microbiota/metabolites-IMF axis".By integrating these insights,we provide a theoretical foundation and define practical research pathways to assess the potential of microbial-based strategies for improving meat quality in swine production.

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作者 Xiaofeng Song [1] Chenglong Jin [2] Ruifan Wu [1] Yongjie Wang [3] Xiaofan Wang [1] 学术成果认领
作者单位 College of Animal Science,State Key Laboratory of Swine and Poultry Breeding Industry/National Engineering Research Center for Breeding Swine Industry/Guangdong Provincial Key Laboratory of Animal Nutrition Control,South China Agricultural University,Guangzhou 510642,China [1] Institute of Animal Science,Guangdong Academy of Agricultural Sciences/Key Laboratory of Animal Nutrition and Feed Science in South China,Ministry of Agriculture and Rural Affairs/Guangdong Provincial Key Laboratory of Animal Breeding and Nutrition,Guangzhou 510640,China [2] Department of Animal Sciences,College of Agriculture and Environmental Sciences,North Carolina Agricultural and Technical State University,Greensboro,NC 27411,USA [3]
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DOI 10.1186/s40104-025-01279-6
发布时间 2026-03-16(万方平台首次上网日期,不代表论文的发表时间)
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