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Branched-chain amino acids in muscle growth:mechanisms,physiological functions,and applications

摘要Skeletal muscle accounts for approximately 40%of body mass and 50%-75%of whole-body protein,playing a cen-tral role in meat production and quality.Efficient protein synthesis in skeletal muscle relies on an adequate supply of nutrient substrates and a balanced amino acid profile.Branched-chain amino acids(BCAA),including leucine(Leu),isoleucine(Ile),and valine(Val),are the most abundant essential amino acids in skeletal muscle and contrib-ute to both protein synthesis and oxidative energy production.Additionally,BCAA function as signaling molecules that regulate gene expression and protein phosphorylation cascades,which significantly influence physiological pro-cesses,such as protein synthesis and degradation,glucose and lipid metabolism,and cell apoptosis and autophagy.These processes are primarily mediated through the PI3K/AKT/AMPK/mTOR signaling pathways.This review sum-marizes BCAA transporters and catabolic metabolism,their role as signaling molecules in regulating protein metabo-lism and glucose and lipid equilibrium,and applications in animal production.These findings offer both theoretical insights and practical guidelines for the precise regulation of feed efficiency and production performance through tai-lored dietary BCAA supplementations.

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作者 Shuyong Xu [1] Guangyong Zhao [1] Mark D.Hanigan [2] Gonzalo Cantalapiedra-Hijar [3] Mengmeng Li [1] 学术成果认领
作者单位 State Key Laboratory of Animal Nutrition and Feeding,College of Animal Science and Technology,China Agricultural University,Beijing 100193,P.R.China [1] School of Animal Sciences,Virginia Tech,Blacksburg,VA 24060,USA [2] Université Clermont Auvergne,INRAE,VetAgro Sup,UMR Herbivores,Saint-Genès-Champanelle 63122,France [3]
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DOI 10.1186/s40104-025-01300-y
发布时间 2026-03-16(万方平台首次上网日期,不代表论文的发表时间)
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