摘要Zearalenone(ZEN)is a non-steroidal estrogenic mycotoxin that extensively contaminates feed and feed ingredients,posing a significant threat to animal health and food safety.Enzymatic degradation of ZEN is regarded as a promis-ing strategy due to its high efficiency and safety.This review provides a comprehensive summary of recent advances in ZEN-degrading enzymes from a novel perspective,encompassing the types and catalytic mechanisms for char-acterizing ZEN-degrading enzymes,the methods for mining ZEN-degrading enzymes,the strategies for improving ZEN-degrading enzymes,and the applications of ZEN-degrading enzymes.The objective of this review is to offer a reliable reference framework for the enzymatic detoxification of ZEN in feed and feed ingredients,as well as to pro-vide insights for mining other mycotoxin degrading enzyme in the future.