摘要甲胎蛋白(alpha-fetal protein,AFP)是一种糖蛋白,自发现伊始,甲胎蛋白一直在相关儿童肿瘤(肝母细胞瘤、卵黄囊瘤、胰母细胞瘤等)的临床诊断中起到重要作用,但诊断作用并不完美,甲胎蛋白有三种异质体(AFP-L1,AFP-L2,AFP-L3),近年来,对其作用机制及功能的研究愈发加深.
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abstractsAlpha-fetoprotein (AFP) has been used as an important tumor marker for hepatoblastoma (HB) and malignant germ cell tumors (GCTs) in pediatric patients.With a low diagnostic specificity,it has 3 isoforms of AFP-L1,AFP-L2 and AFP-L3.This review summarizes recent advances in researches on AFP and its variants.
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