摘要Diminished ovarian reserve (DOR) is a disorder of ovarian func-tion in which the ovary loses its normal reproductive potential,including decreasing oocyte quantity and quality.The disorder is associated with infertility in women of reproductive age with reg-ular menses and poor response to controlled ovarian hyperstimula-tion (Broekmans et al.,2009).Multiple etiologies,such as autoimmunity,environmental factors,and iatrogenic factors,have been reported to significantly contribute to DOR (Tal and Seifer,2013).Genetic defects have been increasingly implicated in human diseases;however,only a few genes (GDF9,FMR1,BMP15,and NR5A1) have been identified as responsible for DOR,and the ge-netic determinants of DOR remain largely unknown (Greene et al.,2014;Jaillard et al.,2020).