Efficient silencing of the multicopy DUX4 gene by ABE-mediated start codon mutation in human embryos

导出学术成果认领

摘要The Dux gene plays an important role in mouse embryo develop-ment(De laco et al.,2017;Hendrickson et al.,2017;Whiddon et al.,2017).It participates in the maternal-to-zygotic transition(MTZ),which mainly includes maternal transcript degradation and zygotic genome activation(ZGA)and is the key process for embryonic devel-opment.Approximately 11-100 copies of the DUX4 gene form a tan-dem cluster in the human genome(Snider et al.,2009,2010).Because of the lack of available embryos and efficient methods for DUX4 gene manipulation,the function of DUX4 in human embryos has not been clearly elucidated.

作者 Yubing Liu ^[1] Xinmei Lu ^[2] Min Ye ^[3] Ling Wang ^[1] Rongxin Tang ^[1] Zhiyong Yang ^[1] Bongkoch Turathum ^[4] Chenchen Liu ^[1] Yujing Xue ^[1] Menghua Wu ^[1] Yannan Yang ^[1] Ermeng Gao ^[1] Di Zhang ^[1] Feng Yang ^[1] Keh-Kooi Kee ^[3] Xingxu Huang ^[5] Guanglei Li ^[5] Ri-Cheng Chian ^[1] 学术成果认领

作者单位 Center for Reproductive Medicine,Tenth People's Hospital of Tongji University,301 Middle Yanchang Road,Shanghai 200072,China ^[1] Center for Reproductive Medicine,Zhongshan Hospital,Fudan University,180 Fenglin Road,Shanghai 200032,China ^[2] Center for Stem Cell Biology and Regenerative Medicine,Department of Basic Medical Sciences,School of Medicine,Tsinghua University,Beijing 100084,China ^[3] Department of Basic Medical Science,Faculty of Medicine Vajira Hospital,Navamindradhiraj University,Bangkok 10300,Thailand ^[4] School of Life Science and Technology,Shanghai Tech University,100 Haike Road,Pudong New Area,Shanghai 201210,China ^[5]

栏目名称 Letter to the Editor

发布时间 2022-11-24

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交