A homozygous frameshift mutation in ADAD2 causes male infertility with spermatogenic impairments

导出学术成果认领

摘要Male infertility is a complex reproductive disorder that impedes a huge number of couples from having children naturally in the world(Agarwal et al.,2021).As an important pathogenic factor of male infer-tility,spermatogenic impairments are mainly characterized by impaired male gamete production,reduced sperm quality,or function(Tournaye et al.,2017).Spermatogenesis is a delicate and complex biological process that requires the collaboration of a large number of proteins performing different biological functions(Liu et al.,2021).

作者 Shixionq Tian ^[1] Ziqi Wang ^[2] Liting Liu ^[3] Yiling Zhou ^[4] Yue Lv ^[5] Dongdong Tang ^[6] Jiaxiong Wang ^[7] Jing Jiang ^[8] Huan Wu ^[9] Shuyan Tang ^[4] Guanxiong Wang ^[3] Hao Geng ^[6] Fangbiao Tao ^[6] Hongbin Liu ^[2] Xiaojin He ^[6] Feng Zhang ^[1] Jinsong Li ^[8] Li Jin ^[4] Tao Huang ^[2] Chunyu Liu ^[1] Yunxia Cao ^[6] 学术成果认领

作者单位 Institute of Metabolism and Integrative Biology,State Key Laboratory of Genetic Engineering,Human Phenome Institute,Obstetrics and Gynecology Hospital,Fudan University,Shanghai 200011,China;Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases,Institute of Reproduction and Development,Fudan University,Shanghai 200011,China ^[1] Center for Reproductive Medicine,Shandong University,Jinan,Shandong 250012,China;Key Laboratory of Reproductive Endocrinology of Ministry of Education,Shandong University,Jinan,Shandong 250012,China ^[2] Reproductive Medicine Center,Department of Obstetrics and Gynecology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China;NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University),Hefei,Anhui 230032,China ^[3] Institute of Metabolism and Integrative Biology,State Key Laboratory of Genetic Engineering,Human Phenome Institute,Obstetrics and Gynecology Hospital,Fudan University,Shanghai 200011,China ^[4] Center for Reproductive Medicine,Shandong University,Jinan,Shandong 250012,China;Key Laboratory of Reproductive Endocrinology of Ministry of Education,Shandong University,Jinan,Shandong 250012,China;Shandong Key Laboratory of Reproductive Medicine,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,Shandong 250012,China ^[5] Reproductive Medicine Center,Department of Obstetrics and Gynecology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China;NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University),Hefei,Anhui 230032,China;Key Laboratory of Population Health Across Life Cycle(Anhui Medical University),Ministry of Education of the People's Republic of China,Hefei,Anhui 230032,China ^[6] Center for Reproduction and Genetics,State Key Laboratory of Reproductive Medicine,The Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou Municipal Hospital,Suzhou,Jiangsu 215002,China ^[7] Genome Tagging Project(GTP)Center,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,Shanghai 200031,China ^[8] Reproductive Medicine Center,Department of Obstetrics and Gynecology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China;Key Laboratory of Population Health Across Life Cycle(Anhui Medical University),Ministry of Education of the People's Republic of China,Hefei,Anhui 230032,China;NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract(Anhui Medical University),Hefei,Anhui 230032,China ^[9]

栏目名称 Letter to the Editor

发布时间 2023-06-08

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交