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Point mutations of homologs as an adaptive solution to the gene loss

摘要Gene loss is common and influences genome evolution trajectories.Multiple adaptive strategies to compensate for gene loss have been observed,including copy number gain of paralogous genes and mutations in genes of the same pathway.By using the Ubl-specific protease 2(ULP2)eviction model,we identify compensatory mutations in the homologous gene ULP1 by laboratory evolution and find that these mutations are capable of rescuing defects caused by the loss of ULP2.Furthermore,bioinformatics analysis of genomes of yeast gene knockout library and natural yeast isolate datasets suggests that point mutations of a homologous gene might be an additional mechanism to compensate for gene loss.

作者 Guosheng Ma ^[1] Xiaojing Zhao ^[2] Xinyi Shentu ^[3] Liye Zhang ^[1] 学术成果认领

作者单位 School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China;Shanghai Clinical Research and Trial Center,Shanghai 201210,China ^[1] School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China ^[2] School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China;State Key Laboratory of Cell Biology,Shanghai Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China ^[3]

关键词 Gene loss ULP2 Homologous gene Compensatory mutation Genome evolution

栏目名称

Original research

DOI 10.1016/j.jgg.2023.02.012

发布时间 2023-08-22（万方平台首次上网日期，不代表论文的发表时间）

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