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ABE-induced PDGFD start codon silencing unveils new insights into the genetic architecture of sheep fat tails

摘要Sheep is an important livestock species raised globally to pro-duce meat,milk,wool,and other by-products.During the Neolithic Revolution,sheep were domesticated in the Fertile Crescent of Southwest Asia around 10,000 years ago(Chessa et al.,2009).Nat-ural and artificial selection has been driving the development of various sheep breeds/ecotypes adapted to different climatic and production conditions.Sheep breeds often differ in coat color,pres-ence or absence of horns,tail shape,etc.Sheep tails can be divided into five main patterns,including fat-long tail,fat-short tail,thin-long tail,thin-short tail,and fat rump(i.e.,'tailless'),which are determined by the length and number of caudal vertebrae as well as the amount of fat deposition.In modern breeding programs,the thin-short tail is considered preferable since other tail patterns have specific issues of concern.For example,fat tails are indicated to be associated with low mating success,animal locomotion,excessive fat deposition,increased production costs,and reduced consumer preference.Similarly,thin long-tailed sheep require tail docking as part of the an-imal management practice,which is a concern for animal welfare.

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作者 Peter Kalds [1] Shuhong Huang [2] Shiwei Zhou [3] Siyuan Xi [2] Yumeng Fang [2] Yawei Gao [2] Kexin Sun [2] Chao Li [2] Bei Cai [4] Yao Liu [2] Yige Ding [2] Qifang Kou [5] Tad Sonstegard [6] Bj?m Petersen [7] Stephen Kemp [8] Baohua Ma [9] Jian-Lin Han [10] Yulin Chen [11] Xiaolong Wang [11] 学术成果认领
作者单位 International Joint Agriculture Research Center for Animal Bio-breeding,Ministry of Agriculture and Rural Affairs/Key Laboratory of Animal Genetics,Breeding and Reproduction of Shaanxi Province,College of Animal Science and Technology,Northwest A&F University,Yangling,Shaanxi 712100,China;Department of Animal and Poultry Production,Faculty of Environmental Agricultural Sciences,Arish University,El-Arish 45511,Egypt [1] International Joint Agriculture Research Center for Animal Bio-breeding,Ministry of Agriculture and Rural Affairs/Key Laboratory of Animal Genetics,Breeding and Reproduction of Shaanxi Province,College of Animal Science and Technology,Northwest A&F University,Yangling,Shaanxi 712100,China [2] International Joint Agriculture Research Center for Animal Bio-breeding,Ministry of Agriculture and Rural Affairs/Key Laboratory of Animal Genetics,Breeding and Reproduction of Shaanxi Province,College of Animal Science and Technology,Northwest A&F University,Yangling,Shaanxi 712100,China;College of Veterinary Medicine,Northwest A&F University,Yangling,Shaanxi 712100,China [3] International Joint Agriculture Research Center for Animal Bio-breeding,Ministry of Agriculture and Rural Affairs/Key Laboratory of Animal Genetics,Breeding and Reproduction of Shaanxi Province,College of Animal Science and Technology,Northwest A&F University,Yangling,Shaanxi 712100,China;Key Laboratory of Ruminant Molecular and Cellular Breeding,School of Agriculture,Ningxia University,Yinchuan,Ningxia 750000,China [4] Ningxia Tianyuan Tan Sheep Farm,Hongsibu,Ningxia 751999,China [5] Acceligen Inc.,St.Paul,MN 55104,United States [6] Institute of Farm Animal Genetics,Friedrich-Loeffler-Institut,Mariensee,Neustadt am Rübenberge 31535,Germany [7] International Livestock Research Institute(ILRI),Nairobi 30709-00100,Kenya [8] College of Veterinary Medicine,Northwest A&F University,Yangling,Shaanxi 712100,China [9] International Livestock Research Institute(ILRI),Nairobi 30709-00100,Kenya;CAAS-ILRI Joint Laboratory on Livestock and Forage Genetic Resources,Institute of Animal Science,Chinese Academy of Agricultural Sciences(CAAS),Beijing 100193,China [10] International Joint Agriculture Research Center for Animal Bio-breeding,Ministry of Agriculture and Rural Affairs/Key Laboratory of Animal Genetics,Breeding and Reproduction of Shaanxi Province,College of Animal Science and Technology,Northwest A&F University,Yangling,Shaanxi 712100,China;Key Laboratory of Livestock Biology,Northwest A&F University,Yangling,Shaanxi 712100,China [11]
栏目名称 Research communications
DOI 10.1016/j.jgg.2023.07.008
发布时间 2024-01-18
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