Permissive role of CTCF-Hoxb7a-Cdkn2a/b axis in the emergence of hematopoietic stem and progenitor cells during zebrafish embryogenesis

导出学术成果认领

摘要Hematopoietic stem and progenitor cells(HSPCs)are a subset population of multi-potent cells with self-renewal capability and dif-ferentiation into all lineages of blood cells(Zhang and Liu,2024).HSPCs arise from the ventral wall of embryonic dorsal aorta,the hemogenic endothelium in the aorta-gonad-mesonephros(AGM)re-gion,tightly controlled by epigenetic,transcriptional,and signaling networks(Wu and Hirschi,2021).However,how developmental hemogenic endothelium performs cell fate surveillances during HSPC emergence and efficiently eliminates them to avoid abnormal hematopoiesis remains elusive.

作者 Wenjuan Zhang ^[1] Xiaofen Liu ^[2] Wenzhi Xue ^[2] Lei Gao ^[2] Dantong Li ^[2] Changbin Jing ^[2] Jian Zhao ^[3] Weijun Pan ^[1] 学术成果认领

作者单位 State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China;CAS Key Laboratory of Nutrition,Metabolism and Food Safety,Shanghai Institute of Nutrition and Health(SINH),University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai 200031,China ^[1] CAS Key Laboratory of Nutrition,Metabolism and Food Safety,Shanghai Institute of Nutrition and Health(SINH),University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai 200031,China ^[2] State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China ^[3]

栏目名称 Research Communications

DOI 10.1016/j.jgg.2024.06.001

发布时间 2024-10-11

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交