换一批摘要Human cancer is one of the leading causes of death worldwide.Tumor heterogeneity and complex microenvironment are major challenges for anti-cancer treatment.A better understanding of the tumor heterogeneity might contribute to more precise diagnosis and treatment.Recent advances in single-cell RNA-sequencing(scRNA-seq)have provided valuable insights into cell fate determi-nation and development in cancer,but the main limitation is that cellular spatial information is lost.Fortunately,spatially resolved transcriptomics technologies have enabled gene expression profiling with spatial coordinates in tissues,which opens up new av-enues for deciphering the cancer spatial structure and accelerating oncological research.
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DOI
10.1016/j.jgg.2024.08.012
发布时间
2025-01-08（万方平台首次上网日期，不代表论文的发表时间）
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