摘要随着21世纪生命科学的迅速发展，生命科学基础知识库急速扩充，生命科学家和医学家都开始重视从基础到临床的成果转化。医师科学家作为一种复合型人才，是联系生命科学和临床实践的纽带。在医师科学家培养方面美国一直处于引领地位，但其培养模式也出现了临床与科研训练时空割裂，没有配套的转化研究课程等弊端。美国威斯康星大学进行了长达5年的课程改革试验，尝试解决这一矛盾。本文介绍了医师科学家培养模式的发展背景，论述了威斯康星大学临床转化研究导师制度的具体改革设计、实施过程及其对我国相关培养模式构建的启示。

abstractsWith the rapid development of life science in the 21st century, the basic knowledge database of life science has expanded rapidly, and both biologists and medical scientists have begun to pay attention to the translational research from foundation into clinical practice. As inter-disciplinary talents, physician-scientists are the link between life science and clinical practice. The United States has been in a leading position in the training of physician-scientist, but its training mode also has drawbacks such as the split of time and space between clinical and scientific training, as well as the lack of supporting translational courses. The University of Wisconsin has been carrying on a five-year experiment of curriculum reform to solve this contradiction. This article introduced the background of the physician-scientist training model, discussed the specific reform design and implementation process of the clinical translational research mentor system in the University of Wisconsin, and its inspiration for the construction of relevant training mode in China.