摘要Semaphorin是神经导向分子家族成员之一,有着广泛的生理功能,其在眼球的发育与视网膜病变的发生过程中具有重要意义.Semaphorin家族成员在角膜、晶状体和视网膜中均有分布,可以影响视网膜、视觉神经系统、角膜神经发育及生长,并保护视网膜神经节细胞(RGCs),从而减少青光眼、视网膜脱离、缺血缺氧性视神经病变引起的RGCs死亡.Semaphorin家族相关的基因突变可能与视网膜变性性疾病有关.其部分成员可以抑制新生血管形成.鉴于Semaphorin家族及其受体在血管神经发育过程中的重要作用,它们极有可能成为将来眼部疾病治疗的新靶点.就Semaphorin家族分子的生物学特性及与眼部疾病的相关性进行综述.

abstractsSemaphorins is the one of guidance molecule families.It is proved to have wide physiological function in the development of neutron and play important role in the pathogenesis of retinal degenerative diseases,gangliocyte apoptosis-related diseases and neovascularization.Previous studies showed that Semaphorins distribute in the cornea,lens and retina.Semaphorins play important role in the development of retina,visual system,cornea nerve and reduce the death of retinal ganglion cells(RGCs)caused by glaucoma,retinal detachment and hypoxic ischemic optic neuropathy.Semaphorin family-related gene mutation may be associated with retinal degenerative diseases.Some of the members could also inhibit angiogenesis.Since semaphorins and its receptors participate in the development of the vasculature and nervous systems,they are implied to be the potential new target of ophthalmopathic treatment.The current ptogress in structure and functions of the semaphorin family along with their relationship with ophthalmopathy were summarized in this study.