摘要血管内皮生长因子(VEGF)家族是一组包含有8个半胱氨酸残基的二聚糖蛋白,它们通过与相应的受体结合而在血管和淋巴管发生中起重要的作用.其中VEGF-A主要参与血管的发生过程,抑制VEGF-A的表达和作用可以起到治疗癌症和防治新生血管性疾病的目的.另外有大量的研究证明,VEGF受体-2(VEGFR-2)还可以在许多非血管组织的细胞中表达,并可能在这些细胞的分化与存活中起到一定的作用.自胚胎期晶状体泡形成时,VEGF和VEGFR-2就可以检测到表达,并且一直持续至成年以后.晶状体自身分泌的VEGF可能通过自分泌或旁分泌在晶状体的分化和发育中起到一定的作用.

abstractsVascular endothelial growth factor (VEGF) family consists of a group of secreted dimeric glycoprotein with a cysteine knot motif of regularly spaced eight cysteine residues,which plays a key role in vasculogenesis,angiogenesis and lymphangiogenesis via their special receptors.VEGF-A,one of VEGF families,is essential for vasculogenesis and angiogenesis.So inhibition of VEGF is available in the treatment of cancer and some diseases of pathological angiogenesis.Some studies imply that VEGF receptor-2 (VEGFR-2)is expressed in some nonvascular tissue and exerts an important role in the differentiation and survival of the cells.The expressions of VEGF and VEGFR-2 in lens epithelial cells(LECs) can be detected in the formation of lens vescle in embryo stage to adult.VEGF secreted by lens itself is concerned with the differentiation and development of lens via autocrine and paracrine.