摘要息肉状脉络膜血管病变(PCV)是一种可引起严重视力损害甚至致盲的特殊性眼底疾病.PCV的发生可能与某些蛋白有关,如血管生成刺激因子和抑制因子的表达失衡而导致脉络膜血管异常,从而促进PCV形成.MMP和组织金属蛋白酶抑制剂通过调控细胞外基质的代谢来调节脉络膜新生血管的形成.氧化型低密度脂蛋白可通过打破MMP和组织金属蛋白酶抑制剂的平衡及改变一些因子水平,从而促进脉络膜新生血管形成.弹性蛋白减少可使血管壁受损扩张,促进脉络膜新生血管形成,同时一些炎性因子,如TGF-β、TNF-α、IL-6及单核细胞趋化蛋白-1等也与脉络膜新生血管形成有关.此外,PCV患者体内C反应蛋白、补体因子及硫氧还原蛋白水平增高,一些其他细胞因子或炎性介质也证实与其有关.本文就近年来在PCV发病过程中相关蛋白的研究进展进行综述.

abstractsPolypoidal choroidal vasculopathy (PCV) is one of the ocular fundus diseases and can cause severe visual impairment or blindness.The occurrence of PCV may be related to certain proteins.The imbalance between angiogenesis stimulating factors and inhibiting factors can cause choroid vascular abnormalities,which promotes PCV formation.Matrix metalloproteinases and tissue inhibitor of metalloproteinases can regulate extracellular matrix metabolism and subsequently regulate the choroid neovascularization.Increase of oxidized low density lipoprotein can break down the balance between matrix metalloproteinases and tissue inhibitor of metalloproteinases,which promotes the choroid neovascularization.The decrease of elastin can lead to damage and expasion of blood vessel walls,and promote the choroid neovascularization.Some inflammatory factors,such as TGF-β,TGF-α,IL-6 and monocyte chemo attractant protein-1 etc,are also associated with the choroid neovascularization.In addition,it was also found that the expression levels of C-reactive protein,complement factors and thioredoxin in PCV patients are higher than those in the normal control.This article reviewed research progression in the related proteins during the process of PCV.