摘要αA晶状体蛋白是晶状体中重要的蛋白成分,具有分子伴侣活性,可调控凋亡、新生血管形成、氧化还原过程及炎症反应,其功能已成为研究热点之一.现在越来越多的研究证实,αA晶状体蛋白不仅存在于晶状体中,也存在于视网膜等其他眼内结构中,不仅可维持内环境的稳定,还在各类眼部疾病,如视神经损伤类疾病、视网膜变性类疾病、眼肿瘤、炎症类疾病和视网膜脉络膜血管类疾病等中表现出相应的变化.本文就αA晶状体蛋白的分布、基本结构、功能及其在眼部疾病中的作用进行综述.

abstractsαA-crystallin is an important protein in lens,with molecular chaperone founction,apoptosis regulation effect,neovascularization regulation,oxidation-reduction reaction process regulation and inflammation reaction regulation.Now,more and more studies have verified that αA-crystallin exists not only in lens,but also in other intraocular structures,such as retina.αA-crystallin can not only maintain the internal environment homeostasis,but also participate in many other eye diseases,such as optic nerve injury diseases,retinal degeneration,ocular neoplasmas,inflammatory diseases and retinal choroidal vascular diseases.This article reviewed the distribution,structure and founction of αA-crystallin and its effects in ocular diseases.