摘要目的:比较近视眼中间视觉环境与明视觉环境下屈光度和高阶像差的变化。方法:采用横断面研究设计，连续纳入2017年2月6—28日在天津市眼科医院拟行屈光手术的近视及近视散光患者71例71眼。采用OPD Scan-Ⅲ屈光力/角膜分析仪测定受检眼中间视觉环境和明视觉环境下的球镜度、柱镜度及全眼高阶像差，对中间视觉环境与明视觉环境下受检眼瞳孔直径、屈光度和高阶像差进行比较。结果:与中间视觉环境比较，受检眼在明视觉环境下瞳孔直径较小，差异有统计学意义( t＝－66.730， P<0.001)。明视觉环境与中间视觉环境环境下受检眼等效球镜度分别为(－6.50±2.38)D和(－6.85±2.75)D，柱镜度分别为(－0.84±0.76)D和(－1.27±0.91)D，差异均有统计学意义(均 P<0.001)；2种环境下测得的球镜度值比较差异无统计学意义( P＝0.212)。中间视觉环境下总高阶像差、总三叶草差及总球差等均方根(RMS)值均较明视觉环境下增加，差异均有统计学意义(均 P<0.001)；中间视觉环境下Zernike多项式各项系数RMS值均较明视觉环境下检测值增加，差异均有统计学意义(均 P<0.001)。 结论:近视和近视散光眼在中间视觉环境下的屈光度和高阶像差均高于明视觉环境下的测定值。

abstractsObjective:To investigate the changes of refraction power and higher-order aberrations under mesopic and photopic vision conditions.Methods:A cross-sectional study was performed.Seventy-one eyes of 71 patients with myopia or myopic astigmatism were enrolled in Tianjin Eye Hospital from February 6 to 28 in 2017.Spherical diopter, cylindrical diopter and higher-order aberrations were examined with NIDEK OPD Scan-Ⅲ.The pupil size, refractive power, total higher-order aberrations and Zernike aberration coefficients were compared between mesopic and photopic conditions.The study protocol was approved by an Ethics Committee of Tianjin Eye Hospital.Written informed consent was obtained from each subject prior to any medical examination.Results:The mean pupil diameter of the photopic conditions was significantly smaller than that of mesopic condition ( t=-66.730, P<0.001). The mean spherical equivalent (SE) were (-6.85±2.75)D and (-6.50±2.38)D under mesopic and photopic conditions, and mean cylindrical diopter were (-1.27±0.91)D and (-0.84±0.76)D, respectively, with statistically significant differences between the two conditions (both at P<0.001). There was no significant difference in spherical diopter between photopic and mesopic conditions ( P=0.212). The root mean square (RMS) values of total higher order aberration, total trefoil, total coma and total spherical aberration under mesopic condition were significantly higher than those under photopic condition (all at P<0.001), and the RMS values of Zernike aberration coefficients were significantly increased in mesopic condition compared with the photopic condition (all at P<0.001). Conclusions:Both refractive power and higher-order aberrations in photopic condition are higher than those in mesopic condition.