摘要目的:探讨青海省西宁市高原地区18岁及以上人群眼压分布特征，建立青海西宁高原人群眼压值参考区间。方法:采用横断面研究方法，于2019年9月至2020年5月在青海省西宁市(海拔2.271 km)对青海省人民医院体检中心接受健康体检的受检者进行眼科检查及眼压测定。受检者均常居西宁市且近3个月未离开西宁市。眼科检查包括视力检查、眼压测定、裂隙灯显微镜检查、眼底照相及眼前后节光学相干断层扫描检查。眼压测定采用Goldmann压平眼压计在眼表局部麻醉下进行。排除有可引起眼压显著改变因素、有影响眼压测量准确性因素及无法行眼压测量者。依据性别、年龄和不同民族对受检者进行分组，比较各组眼压值分布及参考区间。结果:纳入体检者6 120人6 120眼，其中男2 850人，女3 270人；年龄18~90岁，平均(45.54±13.85)岁。青海西宁高原地区人群眼压平均值为(14.32±1.93)mmHg(1 mmHg＝0.133 kPa)，参考区间为10.54~18.10 mmHg；男性眼压平均值为(14.42±1.98)mmHg，参考区间为10.54~18.30 mmHg；女性眼压平均值为(14.23±1.88)mmHg，参考区间为10.55~17.91 mmHg，男性眼压值高于女性，差异有统计学意义( t＝3.71， P<0.001)。汉族、藏族、回族和其他民族人群眼压分别为(14.38±1.91)、(13.93±2.06)、(14.21±1.87)和(13.94±1.95)mmHg，总体比较差异有统计学意义( F＝6.73， P<0.001)，其中汉族受检者眼压值明显高于藏族、回族及其他少数民族，差异均有统计学意义(均 P<0.05)。 结论:青海西宁高原地区人群与正常海拔地区相比眼压参考区间偏低。

abstractsObjective:To investigate the distribution of intraocular pressure (IOP) in high-altitude population aged 18 years and over in Xining, Qinghai and establish the reference interval (RI) of IOP.Methods:A cross-sectional study was conducted in Xining, Qinghai Province at 2.271 km above sea level from September 2019 to May 2020.Ophthalmic examinations and IOP measurement were conducted among subjects from Physical Examination Center of Qinghai Provincial People's Hospital.The subjects who had been living in Xining without leaving for three months were enrolled.Ophthalmic examinations included vision examination, IOP measurement, slit-lamp microscopy, fundus photography, anterior and posterior segment optical coherence tomography.IOP was measured using Goldmann applanation tonometry under local anesthesia.Subjects with factors that could cause significant changes in IOP and affect the accuracy of IOP measurement, and those who were unable to receive IOP measurement were excluded.Subjects were grouped according to sex, age and ethnicity, and the distribution and RI of IOP were compared among all groups.This study adhered to the Declaration of Helsinki.The study protocol was approved by the Ethics Committee of Beijing Tongren Hospital, Capital Medical University (No.TRECKY2017-024). Written informed consent was obtained from each subject.Results:A total of 6 120 subjects (6 120 eyes) aged 18-90 years old were enrolled, including 2 850 males and 3 270 females with average age of (45.54±13.85) years.The average IOP of high-altitude population in Xining, Qinghai Province was (14.32±1.93) mmHg (1 mmHg=0.133 kPa), with the RI of 10.54-18.10 mmHg.The average IOP was (14.42±1.98) mmHg in male with the RI of 10.54-18.30 mmHg, (14.23±1.88) mmHg in female with the RI of 10.55-17.91 mmHg.The IOP of male was higher than that of female ( t=3.71, P<0.001). The IOP of Han, Tibetan, Hui and other nationalities were (14.38±1.91), (13.93±2.06), (14.21±1.87), (13.94±1.95) mmHg, respectively, with a statistically significant overall difference ( F=6.73, P<0.001). The IOP of Han nationality was significantly higher than that of Tibetan, Hui and other nationalities, and the differences were statistically significant (all at P<0.05). Conclusions:RI of IOP in high-altitude population from Xining, Qinghai is lower compared with normal altitude area.