摘要目的:探讨轴向球差渐进调制型非球面人工晶状体(IOL)在模型眼中的成像质量及抗偏心性能。方法:采用基于光学模拟软件的光线追踪法，在模型眼中分别评价轴向球差渐进调制型PRS60A、球差为-0.27 μm的Tecnis Z9000、球差为0 μm的SofPort AO和球面SA60AT IOL 4种IOL在居中及偏心情况下的成像质量。设定瞳孔直径分别为3.0、4.0和5.0 mm，IOL偏心量分别为0、0.25、0.50、0.75 mm，计算并绘制各条件下的调制传递函数(MTF)曲线。对每种IOL分别进行1 000次随机偏心模拟，偏心量为0~0.5 mm，对模拟结果进行蒙特卡洛分析。结果:在3.0、4.0和5.0 mm瞳孔直径条件下，Tecnis Z9000 IOL居中时MTF值最高，成像质量最佳；当偏心量>0.50 mm时，其MTF值明显下降，成像质量显著降低。PRS60A IOL在各瞳孔直径条件下居中和偏心时成像质量多数情况下优于SofPort AO和SA60AT IOL。蒙特卡洛分析显示，PRS60A IOL的术后效果具有较好的可重复性和可预测性，总体成像质量优于恒定球差型IOL。结论:在模型眼中，轴向球差渐进调制型非球面IOL较恒定球差型IOL，具有较好的成像质量及更强的偏心误差耐受性。

abstractsObjective:To investigate the imaging quality and anti-eccentricity performance of axial modulation aspherical intraocular lens (IOL) in model eyes.Methods:A ray-tracing program of optical simulation software was used to evaluate the imaging quality of four different IOLs, including PRS60A IOL, Tecnis Z9000 with -0.27 μm spherical aberration aspherical IOL, SofPort AO with 0 μm spherical aberration aspherical IOL and SA60AT spherical IOL under the condition of either centration or decentration. Modulation transfer functions (MTF) under pupil diameters of 3.0, 4.0, and 5.0 mm and IOL decentrations of 0, 0.25, 0.50, and 0.75 mm were calculated and plotted. A Monte Carlo analysis was performed after 1 000 simulations of IOL decentration, ranging from 0 to 0.5 mm, randomly conducted for every IOL.Results:Under 3.0, 4.0, and 5.0 mm pupil diameters, the centered Tecnis Z9000 IOL had the highest MTF value and the best imaging quality, and when the eccentricity was greater than 0.50 mm, the MTF value decreased significantly, and the imaging quality was significantly reduced. In most cases, the PRS60A IOL was superior to the SofPort AO and SA60AT IOLs when centered and eccentric at various pupil diameters. Monte Carlo analysis showed that the postoperative effects of PRS60A IOL were relatively repeatable and predictable, and the overall imaging quality was better than that of a fixed spherical aberration IOL.Conclusions:Compared with the fixed spherical aberration IOL, the progressive modulation type aspheric IOL of axial spherical aberration has better imaging quality and tolerance to eccentricity errors in model eyes.