摘要Objective: To investigate the immunomodulatory activity of ether insoluble phenolic components of n-butanol fraction (EPC-BF) of flaxseed in rat. Methods: Immunomodulatory activity of EPC-BF was assessed in rat at oral doses of 150 and 300 mg/kg using neutrophil adhesion test, heamagglutination test and measuring delayed type hypersensitivity response. Results: EPC-BF modulates immune response by significantly reducing cell-mediated immune response at oral dose 150 mg/kg but not at dose 300 mg/kg. However, EPC-BF did not affect on the neutrophil adhesion and humoral immunity at both the studied doses. Conclusion: EPC-PC modulates immune response by reducing cell-mediated immune response at lower dose but not at higher dose, which could be due to the presence of both immunostimulant and immunosuppressant phenols together in EPC-BF. These studies suggest that EPC-BF could be a promising source for new immune modifier.