首页 > 亚太热带生物医学杂志（英文版） > Anti-hypercholesterolemic and anti-hyperglycaemic effects of conventional and supercritical extracts of black cumin (Nigella sativa)

Anti-hypercholesterolemic and anti-hyperglycaemic effects of conventional and supercritical extracts of black cumin (Nigella sativa)

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摘要Objective:To explore the hypoglycaemic and hypocholesterolemic potential of conventional and supercritical extracts of black cumin.Methods:Purposely,rat modelling was carried out for 2 months by designing three studies i.e.study Ⅰ (normal rats),study Ⅱ (hyperglycaemic rats) and study Ⅲ (hypercholesterolemic rots).Each study was further divided into three groups based on diet i.e.control,functional diet (contained extract of black cumin prepared by using conventional solvent) and nutraceutical diet (contained extract of black cumin prepared by supercritical fluid extraction system).Results:During whole trial,an abating trend was observed in the level of serum cholesterol with maximum reduction (12.8％) in nutraceutical group of study Ⅲ.Low density lipoprotein and triglyceride level was also lowered maximum in study Ⅲ as 17.1％ and 11.6％,respectively.Whereas,highest decline in glucose level was in nutraceutical group of study Ⅱ as 11.2％.Conclusions:Inclusion of black cumin extracts in diet significantly lowers the occurrence of hyperglycaemia and hypercholesterolaemia.Furthermore,hypoglycaemic and hypocholesterolemic potential of nutraceutical diet is more prominent as compared to functional diet.

作者单位 National Institute of Food Science and Technology, Faculty of Food, Nutrition and Home Sciences, University of Agriculture,Faisalabad, Pakistan ^[1] Department of Agriculture and Food Technology, Karakoram International University, Gilgit-Baltistan, Pakistan ^[2] UQ Diamantina Institute, Translational Research Institute, Faculty of Medicine, The University of Queensland, 37 Kent Street Woolloongabba, Brisbane, QLD 4102, Australia;Department of Food, Nutrition, Dietetics and Health, Kansas State University, Manhattan, KS 66506, USA ^[3]

关键词 Black cumin Functional food Nutraceuticals Supercritical extract Hyperglycaemia Hypercholesterolaemia

栏目名称

Basic research

发布时间 2018-01-09（万方平台首次上网日期，不代表论文的发表时间）

基金项目

This research project was partially supported by Higher Education Commission,Pakistan under Pak-US Science and Technology Cooperation Program Phase Ⅳ（(Project Grant 10/01/10-09/30/12)） :project entitled "Establishment of Functional and Nutraceutical Food Research Section at the National Institute of Food Science and Technology,University of Agriculture,Faisalabad,Pakistan"

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