摘要Objective:To identify the anti-inflammatory activity through two murine models and in the median Lethal Dose (LD50) of three dietary supplements that contain Moussonia deppeana. Methods:The anti-inflammatory activity of three dietary supplements (Cicatrisan/Gastricus?, Gastinol?, and Gastrovita?) EtOH extracts was evaluated by TPA and by carrageenan murine models; also, median Lethal Dose (LD50) was determined. Verbascoside was quantified by High-Performance Liquid Chromatography.β-sitosterol, stigmasterol and the mixture of ursolic and oleanolic acids were identified in all supplements by TLC; however, none of these dietary supplements contain verbascoside.Results: For the TPA model, Cicatrisan/Gastricus? generated a notable effect with 38.24% inhibition. While in the carrageenan model, it also exhibited noteworthy anti-inflammatory activity of ear edema with 66.39% of paw edema inhibition at 150 mg/kg, followed by Gastinol? and Gastrovita? with 50% at 300 mg/kg. Finally, LD50 was >2 g/kg for all supplements, when was administered intragastrically and Body Weight (BW) gain in mice was not altered after 14 days.Conclusions: Of the three food supplements containingM. deppeana, only the EtOH extract from the Cicatrisan/Gastricus? formulation (tablets) showed significant anti-inflammatory activity in both experimental models and the LD50was > 2 g/kg.