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Homozygosity for the CD1E★02 allele is associated with a resistance to Plasmodium falciparum malaria infection in Gabonese school children

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摘要Objective:To explore the possible association between polymorphisms in CD1 genes and both asymptomatic and mild Plasmodium falciparum infection.Methods: Two clusters of 85 school children, from the village of Dienga (Gabon) were investigated. The first group was analysed for the prevalence and the multiplicity of asymptomatic Plasmodium falciparum infection, whereas the second group was screened for the frequency of malarial attacks. Results: Our findings showed that homozygosity for the CD1E*02 allele was associated with a low frequency of malarial attacks. Furthermore, a strong association between CD1E*02 homozygotes and the resistance to multiple malarial attacks was identified. The CD1A*01 allele showed a weak association with a small number of malarial attacks.Conclusion: Our results suggest a possible role of CD1E polymorphisms in malaria protection among school children and that CD1e molecules are involved in anti-malarial immunity.

作者单位 Centre International de Recherches Medicales de Franceville (CIRMF), BP 769, Franceville, Gabon;Congolese Foundation for Medical Research, Brazzaville, Republic of Congo ^[1] Centre International de Recherches Medicales de Franceville (CIRMF), BP 769, Franceville, Gabon;Laboratory of Molecular and Cellular Biology, University of Sciences and Techniques of Masuku (USTM), Franceville, Gabon ^[2] Laboratoire d'Immunologie et d'Histocompatibilite AP-HP, IUH and INSERM U662, Hopital Saint-Louis, Paris, France;Faculty of Medicine, Nilton Lins University, Manaus, Amazonia, Brazil ^[3] Centre International de Recherches Medicales de Franceville (CIRMF), BP 769, Franceville, Gabon;EA 4575 Analytical and pharmaceutical developments applied to neglected diseases and to counterfeits, Bordeaux Segalen University, Bordeaux, France ^[4] Laboratoire d'Immunologie et d'Histocompatibilite AP-HP, IUH and INSERM U662, Hopital Saint-Louis, Paris, France ^[5]

关键词 CD1E CD1A Malaria GPI Gabon

DOI 10.1016/j.apjtm.2017.01.017

发布时间 2017-07-04（万方平台首次上网日期，不代表论文的发表时间）

基金项目

:We have received 2 financial supports from Gabon International Centre of Medical Research (Franceville, Gabon) that is supported by the government of Gabon, Total-Gabon and the French Ministry of Foreign Affairs, Histocompatibility and Immunology Laboratory AP-HP, IUH and INSERM U662, Saint-Louis hospital（France (Laboratory)）

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