摘要Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth.The bacterial resistance against antibiotics is a serious issue for public health.Today,new therapeutic targets other than the bacterial wall were deciphered.Quorum sensing or bacterial pheromones are molecules called auto-inducer secreted by bacteria to regulate some functions such as antibiotic resistance and biofilms formation.This therapeutic target is well-studied worldwide,nevertheless the scientific data are not updated and only recent researches started to look into its potential as a target to fight against infectious diseases.A major concern with this approach is the frequently observed development of resistance to antimicrobial compounds.Therefore,this paper aims to provide a current overview of the quorum sensing system in bacteria by revealing their implication in biofilms formation and the development of antibiotic resistance,and an update on their importance as a potential target for natural substances.