摘要Rationale:Cryptococcal infections commonly occur in immunosuppressed patients and are uncommon in immunocompent persons.Patient concerns:A 32 year old lady,active smoker presented with right chest pain,dry cough and loss of weight.Initial chest radiograph showed a lobulated lung mass in the right lower lobe.She developed headache and right cranial nerve palsy during admission.Various investigations were done including lumbar puncture,brain and chest imaging.Diagnosis:Cryptococcal meningitis with pulmonary cryptococcoma.Interventions:She received five months of effective antifungal treatment;however,the patient did not respond well.Subsequently,removal of pulmonary cryptococcoma was done.Outcomes:Her condition improved and she no longer had any headache.Lessons:Disseminated cryptococcosis is rare in immunocompetent patient.Our case highlights the importance of high index of suspicion and we postulate that lobectomy helped in reducing the cryptococcal burden in her body,thus facilitating better response to antifungal therapy.