Liposomes as immunological adjuvants and delivery systems in the development of tuberculosis vaccine: A review

导出学术成果认领

摘要Liposomes are phospholipid bilayer vesicles, which are biocompatible, biodegradable and nontoxic vehicles suitable for numerous drug and gene delivery applications. In this review, we discuss the prospect of using liposome technology in the development of a vaccine for tuberculosis. Tuberculosis remains an important health problem that requires the development of an effective vaccine, especially since the only approved vaccine for it continues to be the Bacille Calmette-Geurin (BCG) one developed 100 years ago. This review focuses on the different applications of liposomes toward achieving this goal. Numerous liposomal formulations showing prospect in the research stage and in clinical trials are discussed.

作者 Nur Ellene Mat Luwi ^[1] Suhana Ahmad ^[1] Ahmad Suhaimi Nurfatihah Azlyna ^[1] Asyikin Nordin ^[1] Maria Elena Sarmiento ^[2] Armando Acosta ^[2] Mohd Nor Norazmi ^[2] Vuk Uskokovi? ^[3] Rohimah Mohamud ^[1] Ramlah Kadir ^[1] 学术成果认领

作者单位 Department of Immunology,School of Medical Sciences,Universiti Sains Malaysia,16150 Kubang Kerian,Kelantan,Malaysia ^[1] School of Health Sciences,Universiti Sains Malaysia,16150 Kubang Kerian,Kelantan,Malaysia ^[2] Department of Mechanical Engineering,San Diego State University,Campanile Dr.5500,San Diego 921982,CA,USA;TardigradeNano LLC,Irvine,CA 92604,USA ^[3]

关键词 Liposomes Tuberculosis vaccine Adjuvant Delivery system Tuberculosis

栏目名称 Review Article

DOI 10.4103/1995-7645.332806

发布时间 2022-03-22

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交