摘要Objective:To investigate the prevalence,antimicrobial resistance and genetic diversity of Staphylococcus(S.)aureus among healthy young adults of 18 to 25 years in Ho Chi Minh City,Vietnam.Methods:A cross-sectional,descriptive study was conducted between December 2023 and December 2024.Nasal swabs were processed for S.aureus isolation,antibiotic susceptibility testing,and PCR-based detection of spa,pvl,and mecA genes.Genetic similarity was assessed using the unweighted pair group method with arithmetic mean cluster analysis.Statistical significance was determined by Chi-square test.Results:In this cross-sectional study of 428 students,the S.aureus carriage rate was 33.9%.Methicillin-resistant S.aureus(MRSA)prevalence was 54.5%(79/145).10%-17%of MRSA isolates exhibited resistance to three to ten antibiotics,with two strains demonstrating resistance to 11 and 12 drugs,respectively.The pvl gene was detected in 5.8%of isolates.55.17%S.aureus strains belonged to ten distinct spa types with 300-bp amplicons.Conclusions:These findings provide valuable insights into S.aureus carriage patterns among youth in Ho Chi Minh City,informing public health strategies for prevention and treatment.