摘要睑板腺功能障碍(MGD)是临床常见的眼表疾病,患病人群大,表现多样,轻重不一.轻者仅表现为眼部不适,重者影响角膜,引起视力下降甚至失明.MGD以睑板腺终末导管的阻塞和睑脂分泌物质和量的异常为主要病理基础,使泪液稳定性下降,引起眼表上皮损伤和炎症细胞的激活,释放炎症因子.MGD相关的角膜病变通常发生在下方角膜缘与睑缘相接触的部位,角膜浸润伴有血管的长入,部分患者合并面部痤疮和其他皮脂腺异常.治疗原则为清洁睑缘、热敷及按摩以促进睑板腺的分泌和排放;补充泪液缓解症状;抗感染和抗炎药物抑制炎症反应,防治组织损伤,重度或有全身疾病者同时给予全身药物治疗;及时处理并发症.

abstractsMeibomian gland dysfunction (MGD) is one of the most common ophthalmologic conditions worldwide.The clinical spectrum of the disease varies.Patients with mild MGD only experience chronic discomfort.Patients with severe dysfunction experience a decrease in vision and then become blind.The pathology of MGD involves meibomian gland destruction and an increase in lipid viscosity that blocks the pore, causing a reduction in glandular lipid secretion and discharge.This leads to a lack of the lipid layer in tear film, therefore causing damage to the ocular surface epithelial cells and inflammation.The keratoconjunctivitis associated with MGD occurs at the inferior corneal area that is in contact with the palpebral margin.Corneal tissue infiltrates the blood vessels.Some patients also suffer from acne and sebaceous gland disorder.Treatment includes cleaning the palpebral margin, supple artificial tear liquid, and treatment for infection and inflammation that prevents ocular tissue damage.Systemic medicine is necessary for patients with severe conditions.Complications need to be treated in a timely manner.