摘要目的 比较准分子激光上皮下角膜磨镶术(LASEK)、经上皮准分子激光角膜切削术(TPRK)治疗低中度近视的临床疗效.方法 回顾性病例研究.收集2014年7月1-31日在南京东南眼科医院行LASEK患者28例(56眼)和行TPRK患者25例(49眼).术后观察上皮愈合时间、裸眼视力(UCVA)和角膜上皮下雾状混浊(haze).术后随访6个月.采用独立样本t检验比较2组数据.结果 术后1周,LASEK组UCVA为5.01±0.05 ,TPRK组为5.06±0.06,2组差异有统计学意义(t=3.89,P＜0.05).术后3、6个月,2组UCVA差异无统计学意义.LASEK组术后上皮愈合时间为(5.8±0.9)d,长于TPRK组[(3.2±0.4)d](t=3.89,P＜0.01).随访期间2组均未发现0.5级以上的haze.结论 TPRK治疗低中度近视安全、有效、准确,相对于LASEK术后上皮恢复更快、视力更好.

abstractsObjective To compare the clinical outcomes between laser epithelial keratomileusis (LASEK) and transepithelial photorefractive keratectomy (TPRK) for the treatment of mild to moderate myopia.Methods In this retrospective case series study, 28 patients (56 eyes) who underwent LASEK (LASEK group) and 25 patients (49 eyes) who underwent TPRK (TPRK group) in Nanjing Southest Eye Hospital were included.Epithelial recovery time, uncorrected visual acuity (UCVA), and haze were compared between the 2 groups using an independent t test.All the patients were followed up for 6 months.Results At 1 week postoperatively, the UCVA in the LASEK group was 5.01±0.05 and was 5.06±0.06 in the TPRK group.There was a significant difference between the two groups (P＜0.05).However, there was no significant difference between the two groups at 3 and 6 months postoperatively (t=0.69, 1.54, P＞0.05).The mean time for epithelial healing in the LASEK group was 5.8±0.9 days and was 3.2±0.4 days in the TPRK group (t=3.89, P＜0.01).No haze (＞0.5) was observed in either group during the follow-up period.Conclusion TPRK is a safe, effective and precise procedure for the correction of mild to moderate myopia, and provides a faster healing time and better UCVA than LASEK.