摘要目的:研究新型光学相干断层扫描血管成像仪(Angio OCT)测量不同屈光度患者黄斑区血管密度的重复性.方法:前瞻性研究.共纳入2016年4—10月于温州医科大学就诊120例受检者的120只右眼.根据等效球镜度(SE)将受检者分为低度近视组(近视度数≤-3.0 D)、中度近视组(-3.0 D<近视度数<-6.0 D)和高度近视组(近视度数>-6.0 D).采用Angio OCT来获取En-Face图像,并通过自动计算软件对视网膜进行分层处理,软件计算视网膜血管密度.采用组内标准差和重测度评估重复性,采用Pearson相关分析评估血管密度与屈光度、眼轴长度的相关性.结果:受检者的年龄为(22.0±5.6)岁,等效球镜度为(-4.80±2.48)D.低度近视组、中度近视组和高度近视组的数据都显示有良好的视网膜血管密度的重复性,且重测度结果都小于6.1％.分析4个象限的血管密度,3组数据结果类似,除了中度近视组最大的血管密度落在鼻侧象限外,其余2组下方象限的血管密度要大于其他3个象限.3组之间差异没有统计学意义.中心凹血管密度与屈光度、眼轴长度呈弱正相关(r=0.190,P=0.037;r=0.246,P=0.007).结论:Angio OCT用于视网膜密度和黄斑中心凹无血管区的测量具有良好的重复性.不同的屈光度数不会影响测量结果的重复性.此外,仅屈光度、眼轴长度与中心凹血管密度成弱正相关.

abstractsObjective: To evaluate the reliability of novel optical coherence tomography angiography (Angio OCT) in measuring macular retinal vascular density with different refractive powers. Methods: One hundred twenty subjects came to regular examination between April to October 2016 in Eye Hospital, Wenzhou Medical University were recruited for this prospective study and the right eyes were selected. Subjects were divided into three groups based on their spherical equivalent (SE): Low myopia group (SE ≤ -3.00 D), Moderate myopia group (from -3.00 D to -6.00 D) and High myopia group (SE>-6.00 D). Angio OCT (RTVue XR, Optovue, USA) was used to create the En-Face images and an automatic identification program segmentedthe retina and then calculated vessel density. Repeatability was assessed by within-subject deviation (Sw) and test-retest (TRT). And a Pearson correlation was used to assess the relationship among vessel density, refractive power and axial length. Results: The age range and SE of subjects was 22.00±5.60 years and-4.80±2.48 D. All three groups showed good repeatability in retinal vascular density calculations. The TRT values were all lower than 6.1％. When analyzing the vascular density of the four quadrants, the inferior quadrant showed larger values than the other three quadrants except for the moderate myopia group in which the repeatability of the nasal quadrant was the worst. Even so, there was no statistical significance found in the three groups. The correlation coefficient between foveal vascular density and refractive power and axial length was 0.19 (P=0.037) and 0.246 (P=0.007), separately. Conclusion: The Angio OCT demonstrates good reliability in measuring macular retinal vascular density and the foveal avascular zone (FAZ). Different refractive powers do not influence the validity of the results. In addition, refractive power and axial length have a weak positive correlation with foveal vascular density.