摘要目的:探讨视觉质量分析系统(OQAS)测量圆锥角膜眼与正常角膜眼之间视觉质量的差异.方法:横断面研究.选取正常角膜屈光不正患者32例(32眼)作为对照组,圆锥角膜患者27例(27眼)作为圆锥角膜组.采用OQAS测量每组在3、4、5mm的人工瞳孔直径下的视觉质量参数调制传递函数截止频率(MTFcutoff)、Streh1比、不同对比度下的OQAS值(OV-100、OV-20、OV-9),组间差异采用独立样本t检验或Mann-Whitney U检验,组内差异采用重复测量资料方差分析及Bonferroni校正.结果:圆锥角膜组在人工瞳孔分别为3、4、5mm时的MTFcutoff、Streh1比、OV-100、OV-20、OV-9均低于对照组(3 mm:t=6.658、6.695、6.660、6.493、6.778;4mm:t=7.106、6.567、7.109、6.802、6.788;5 mm:t=6.148、7.254、6.158、6.446、7.210;P均＜0.001).对照组及圆锥角膜组内MTFcutoff、Streh1比、OV-100、OV-20、OV-9在不同人工瞳孔大小的组内比较差异有统计学意义(对照组:F=42.205、28.335、42.559、32.621、30.372;圆锥角膜组:F=15.732、11.533、15.625、13.870、10.495;均P＜0.001).结论:双通道OQAS测量结果表明圆锥角膜的视觉质量较正常眼明显下降,圆锥角膜及正常眼的视觉质量均随着瞳孔增大而下降.

abstractsObjective:To analyze the difference in optical quality between a normal cornea and keratoconus using an optical quality analysis system (OQAS).Methods:This cross-sectional study included 32 normal eyes and 27 keratoconus eyes.Optical qualities were measured by OQAS.Modulation transfer function cutoff frequency (MTFcutoff),Strehl ratio and OQAS values (OV-100,OV-20,OV-9) in artificial pupil diameters of 3 mm,4 mm and 5 mm were analyzed by independent t test or Mann-Whitney U test,the difference among groups was analyzed by ANOVA for repeated measurement and Bonferroni post hoc t test.Results:MTFcutoff,Strehl ratio and OQAS values of the keratoconus group in artificial pupil diameters of 3 mm,4 mm and 5 mm were all lower than those of the control group (3 mm:t=6.658,6.695,6.660,6.493,6.778;4 mm:t=7.106,6.567,7.109,6.802,6.788;5 mm:t=6.148,7.254,6.158,6.446,7.210;all P＜0.001).Both in the control group and in the keratoconus group,the MTFcutoff,Strehl ratio,OV-100,OV-20 and OV-9 varied from artificial pupil diameters (control group:F=42.205,28.335,42.559,32.621,30.372;keratoconus group:F=15.732,11.533,15.625,13.870,10.495;all P＜0.001).Conclusions:The optical qualities of keratoconus measured by OQAS are worse than normal eyes.Both in keratoconus and normal eyes,the optical qualities decline as pupil size increases.