摘要目的：:探讨7～18岁青少年角膜生物力学及校正眼压与屈光状态的内在关系。方法：:横断面研究。选择2017年11月至2018年2月于中山大学中山眼科中心屈光门诊就诊的中国青少年325例，年龄7～18岁，等效球镜度（SE）-10.25～+16.50 D。采用IOLMaster测量眼轴长度（AL），Corvis ST测量角膜生物力学参数及生物力学校正眼压（bIOP），Pentacam测量眼前节生物学参数。按照右眼SE将受检者分为高度近视、中低度近视、正视和远视组。采用Pearson或Spearman相关分析SE与角膜生物力学参数的相关性。用协方差分析比较4组的角膜生物力学参数差异，用方差分析比较4组间的bIOP差异。结果：:SE越偏向近视，第二次压平速率（VA2， r=0.180， P=0.001）越快，峰值距离（PD， r=-0.273， P<0.001）和形变幅度（DA， r=-0.167， P=0.002）越大。AL越长，PD（ r=0.355， P<0.001）越大，VA2（ r=-0.138， P=0.021）越快。4组间PD（ F=9.372， P<0.001）、DA（ F=4.425， P=0.005）和VA2（ F=4.961， P=0.002）的总体差异有统计学意义，进一步比较发现，PD、DA和VA2绝对值在高度近视、中低度近视、正视、远视组间依次下降，差异均有统计学意义（均 P<0.05）。高度近视组（102.04±19.59）和中低度近视组（98.95±16.62）的角膜硬度参数（SP-A1）差异无统计学意义，但中低度近视组比正视组（107.49±18.66， P=0.010）和远视组（108.98±20.20， P=0.004）的SP-A1低，差异有统计学意义。眼压（IOP）和bIOP均与SE无相关性。 结论：:7～18岁青少年SE越偏向近视，角膜硬度越低。无论是否校正角膜生物力学因素的影响，眼压均与屈光度无关。

abstractsObjective::To explore the relationship between corneal biomechanics, biomechanically corrected intraocular pressure (bIOP) and refractive status in Chinese juveniles.Methods::This was a cross-sectional study conducted at the Zhongshan Ophthalmic Center between November 2017 and February 2018. A total of 325 Chinese juveniles, aged 7 to 18 years with a spherical equivalent (SE) refraction between -10.25 and +16.50 diopters (D) were included. Axial length (AL) was measured using an IOLMaster. Corneal biomechanical metrics and bIOP were measured using a Corvis ST, and corneal biological parameters were measured using a Pentacam. Participants were divided into 4 groups: high myopia, low-to-moderate myopia, emmetropia, and hyperopia based on the right eye SE. Differences in corneal biomechanical characteristics among the 4 groups were analyzed by covariance analysis, while differences in bIOP were analyzed by ANOVA.Results::Higher myopic SE was significantly correlated with faster corneal velocity during the second applanation moment (VA2, r=0.180, P=0.001), the longer peak distance (PD, r=-0.273, P<0.001) and larger deformation amplitude (DA, r=-0.167, P=0.002). A longer AL was significantly correlated with a faster VA2 ( r=-0.138, P=0.021) and longer PD ( r=0.355, P<0.001). There were significant differences among the 4 groups in PD ( F=9.372, P<0.001), DA ( F=4.425, P=0.005), and VA2 ( F=4.961, P=0.002). Further study found that the PD, DA and absolute value of VA2 successively decreased in high myopia, low-to-moderate myopia, emmetropia, and hyperopia groups (all P<0.05). The differences in the stiffness parameter at the first applanation (SP-A1) in high myopia (102.04±19.59) and low-to-moderate myopia groups (98.95±16.62) were not significant ( P>0.05), while the SP-A1 of the low-to-moderate myopia group was significantly greater than that of the emmetropia (107.49±18.66, P=0.010) and hyperopia groups (108.98±20.20, P=0.004). There was no significant correlation between intraocular pressure (IOP)/bIOP and SE. Conclusions::Corneal stiffness seems to decrease with a higher myopic SE in Chinese juveniles aged 7 to 18 years. IOP, whether it was corrected by corneal biomechanics or not, is not related to refractive status.