摘要目的：:应用SD-OCT分析不同近视人群Bruch膜开口-最小盘沿宽度（BMO-MRW）与RNFL的变化特征及相关性。方法：:系列病例研究。连续纳入2024年9—12月于安徽理工大学第一附属医院眼科就诊近视患者103名（202眼），其中男52名，女51名，年龄18~25岁。按SE将患者分为低度近视组60眼，中度近视组73眼，高度近视组69眼。使用海德堡SD-OCT进行视神经结构测量，通过青光眼高级扫描模式（GMP）获取各组BMO-MRW、RNFL厚度，分别记录鼻侧、颞侧、鼻上、鼻下、颞上、颞下及盘周整体参数值。数据分析采用Kruskal-Wallis H非参数检验和Spearman相关分析。 结果：:3组间BMO-MRW在颞侧象限差异有统计学意义（ H=7.56， P=0.023），进一步组间分析，高度近视组厚于低度近视组（ Z=-2.72， P=0.019）。3组间RNFL厚度在颞侧象限差异有统计学意义（ H=18.22， P<0.001），其中，高度近视组、中度近视组均厚于低度近视组（ Z=-3.68、-3.83，均 P<0.05）。高度近视组中，颞侧和颞上象限BMO-MRW与RNFL厚度呈正相关（ r=0.55、0.54，均 P<0.05）；中度近视组中，盘周整体BMO-MRW与RNFL厚度呈正相关（ r=0.37， P=0.001）。颞侧象限BMO-MRW与AL无显著相关（ P>0.05）、与角膜曲率呈正相关（ r=0.21， P=0.003）。颞侧象限RNFL厚度与AL呈正相关（ r=0.14， P=0.043）。 结论：:随着近视屈光度增加，颞侧象限BMO-MRW与RNFL厚度增加。在高度近视中，颞侧BMO-MRW是一个更稳定的量化近视眼视乳头周围RNFL的参数。

abstractsObjective::To analyze the characteristics and correlations of Bruch’s membrane opening-minimum rim width (BMO-MRW) and retinal nerve fiber layer (RNFL) thickness in different myopia cohorts using spectral-domain optical coherence tomography(SD-OCT).Methods::A case-series study was conducted. A total of 103 patients (202 eyes) with myopia who visited the Ophthalmology Department of the First Affiliated Hospital of Anhui University of Science and Technology between September and December 2024 were enrolled in this study. The cohort included 52 males and 51 females aged 18-25 years. Based on spherical equivalent, the patients were categorized into a low myopia group (60 eyes), a moderate myopia group (73 eyes), and a high myopia group (69 eyes). Optic nerve structure measurements were performed using Heidelberg Spectralis SD-OCT. The Glaucoma Module Premium (GMP) protocol was applied to obtain BMO-MRW and RNFL thickness values for each group. Parameters were recorded in the nasal, temporal, superonasal, inferonasal, superotemporal, inferotemporal, and global peripapillary regions. Data analysis was performed using the Kruskal-Wallis H test and Spearman correlation analysis. Results::A statistically significant difference in BMO-MRW was observed among the three groups in the temporal quadrant ( H=7.56, P=0.023). Post hoc analysis revealed that the high myopia group had significantly greater BMO-MRW than the low myopia group ( Z=-2.72, P=0.019). Similarly, RNFL thickness also differed significantly among the three groups in the temporal quadrant ( H=18.22, P<0.001). Both the high and moderate myopia groups exhibited greater RNFL thickness compared to the low myopia group ( Z= -3.68 and-3.83, respectively; both P<0.05). In the high myopia group, positive correlations were found between BMO-MRW and RNFL thickness in both the temporal and superotemporal quadrants ( r=0.55, 0.54, both P<0.05). In the moderate myopia group, a positive correlation was observed between global peripapillary BMO-MRW and RNFL thickness ( r=0.37, P<0.01). Temporal quadrant BMO-MRW showed no significant correlation with axial length (AL) ( P>0.05) but was positively correlated with corneal curvature ( r=0.21, P=0.003). In contrast, temporal quadrant RNFL thickness was positively correlated with AL ( r=0.14, P=0.043). Conclusion::Both BMO-MRW and RNFL thickness increase in the temporal quadrant with a higher degree of myopia. In high myopia, temporal BMO-MRW serves as a more stable parameter for quantifying the peripapillary RNFL thickness.