摘要目的 通过检测子痫前期及子痫患者血中血小板膜糖蛋白(GP)Ⅱb/Ⅲa、Pt和肝肾功能指标,以探讨血小板活化因子及肝肾功能指标在子痫前期及子痫中的变化及意义.方法 分别检测子痫前期及子痫(子痫前期-子痫组,60例;其中轻度子痫前期组22例,重度子痫前期-子痫组38例)、正常孕晚期(正常孕晚期组,30例)、正常未孕妇女(正常未孕组,20例)GPⅡb/Ⅲa、Pt和肝肾功能指标.结果 GPⅡ b/Ⅲa:重度子痫前期-子痫组与正常未孕组、正常孕晚期组、轻度子痫前期组比较差异均有统计学意义(P<0.01).Pt:重度子痫前期-子痫组比正常未孕组、正常孕晚期组、轻度子痫前期组均明显降低,差异有统计学意义(P<0.01).除ALB外,重度子痫前期-子痫组肝肾功能指标与正常孕晚期组、轻度子痫前期组比较差异均有统计学意义.结论 联合检测GP Ⅱb/Ⅲa、Pt和肝肾功能指标,对重度子痫前期及子痫患者诊断血小板活化、肝肾脏器损害有重要临床意义.

abstractsObjective To discuss the role of platelet-actived factors and hepatic and renal function in the development of pre-eclampsia and eclampsia by detecting the levels of the GP Ⅱb/Ⅲa in the blood, Pt and hepatic and renal function of the patients with pre-eclampsia and eclampsia. Method GP Ⅱb/Ⅲa, Pt and hepatic and renal function were measured in the normal non-pregnancy women, normal late-pregnancy women and pre-eclampsia and eclampsia women. Results The level of GP Ⅱb/Ⅲa in patients with severe pre-eclampsia and eclampsia was higher than that in non-pregnancy, normal late-pregnancy and mild pre-eclampsia (P<0.01). The count of Pt in patients with severe pre-eclampsia and eclampsia was lower than that in non-pregnancy, normal late-pregnancy and mild pre-eclampsia (P<0.01). Except ALB, the hepatic and renal function had significant difference among severe pre-eclampsia and eclampsia, normal late-pregnancy and mild pre-eclampsia. Conclusion Detecting the GP Ⅱb/Ⅲa, Pt and hepatic and renal function have clinical significance in severe pre-eclampsia and eclampsia.