摘要目的 探讨继发性全面性癫痫(SGTCS)发作患者的神经心理特征.方法 收集20例SGTCS病例,统计患者一般资料和SGTCS发作次数,将患者分为SGTCS高发组(发作次数≥20次,10例)和SGTCS低发组(发作次数<20次,10例),并对患者的言语智商(VIQ)、操作智商(PIQ)、全量表智商(FIQ)、文字认知测试、数字认知测试、二元选择反应测试(BCRT)-反应时间、电脑视觉搜索任务测试(CVST)-反应时间和恶化评分进行评估.结果 SGTCS高发组VIQ、PIQ、FIQ、文字认知均显著低于SGTCS低发组[(94.9±20.9)分比(116.0±17.8)分,(95.3±16.8)分比(117.8±12.4)分,(94.3±20.6)分比(118.0±12.8)分,(14.1±4.9)分比(19.8±2.1)分](P<0.05或<0.01),CVST-反应时间和恶化评分均显著高于SGTCS低发组[(16.6±5.1)s比(11.9±2.0)s,(3.1±1.4)分比(1.6±1.1)分](P<0.05).结论 SGTCS在智力和信息收集方面随着疾病程度的进展而退化.

abstractsObjective To investigate the neuropsychological characteristics of secondarily generalized tonic clonic seizures (SGTCS). Methods Twenty patients of SGTCS were divided into higher SGTCS group (the times of SGTCS ≥ 20,10 cases) and lower SGTCS group (the times of SGTCS < 20,10 cases). Investigated the tests of verbal intelligence quotient (VIQ), procedure intelligence quotient (PIQ) and full-scale intelligence quotient(FIQ), as well as cognitive test, BCRT-reaction time, CVST-reaction time and the deterioration scores. Results The VIQ, PIQ, FIQ and cognitive test of higher SGTCS group were significantly lower than those in lower SGTCS group[(94.9 ± 20.9) scores vs (116.0 ± 17.8) scores, (95.3 ±16.8) scores vs(117.8 ± 12.4) scores, (94.3 ±20.6) scores vs (118.0±12.8) scores, (14.1±4.9) scores vs (19.8 ± 2.1)scores] (P < 0.05 or < 0.01), and the outcomes of CYST-reaction time and the deterioration scores were significantly higher than those in lower SGTCS group [(16.6 ± 5.1) s vs (11.9 ± 2.0) s, (3.1 ± 1.4) scores vs(1.6 ± 1.1) scores](P < 0.05). Conclusion Intellectual and information gathering capability of SGTCS were deteriorated with the degree of disease worsened.