摘要目的 探讨血管紧张素Ⅱ1型受体阻断剂治疗原发性高血压的临床疗效及其对胰岛素敏感性的影响.方法 选择原发性高血压患者80例作为研究对象,按随机数字表法分为治疗组和对照组,治疗组40例,采用血管紧张素Ⅱ1型受体阻断剂替米沙坦治疗；对照组40例,采用钙离子拮抗剂氨氯地平治疗,疗程均为8周.比较两组的临床疗效和胰岛素敏感性.结果 治疗组总有效率为75.0％( 30/40),对照组总有效率为72.5％( 29/40),两组比较差异无统计学意义(P＞0.05).治疗组和对照组治疗前胰岛素敏感指数(IsI)分别为-4.5±0.8和-4.7±0.7,差异无统计学意义(P＞0.05),治疗组治疗后ISI为-3.2±0.5,对照组治疗后为-4.4±0.6,两组比较差异有统计学意义(P＜0.05).结论 血管紧张素Ⅱ1型受体阻断剂治疗原发性高血压效果明显,同时可增加胰岛素的敏感性.

abstractsObjective To explore the clinical curative effects of angiotensin Ⅱ 1 receptor blocker in treating primary hypertension and its effects on insulin sensitivity.Methods Eighty primary hypertension patients were divided into the treatment group ( 40 cases,treated with telmisartan ) and the control group (40cases,treated with amlodipine) by random digits table.The treatment period was 8 weeks.After treatment,the clinical curative effect and insulin sensitivity was compared between the two groups.Results In treatment group and control group,the total effective rate was 75.0％(30/40) and 72.5％(29/40),there was no significant difference (P＞ 0.05 ).Before treatment,the insulin sensitivity index ( ISI ) in treatment group and control group was -4.5 ±0.8 and -4.7 ±0.7 (P ＞ 0.05),after treatment,the ISI was -3.2 ±0.5 and -4.4 ±0.6 (P＜0.05).Conclusion The clinical curative effects of angiotensin Ⅱ 1 receptor blocker in treating primary hypertension are obvious,and may improve the insulin sensitivity.