摘要目的 观察苯磺酸左旋氨氯地平联合贝那普利治疗原发性高血压并左室肥厚的临床疗效.方法 将98例原发性高血压并左室肥厚患者按随机数字表法分为两组,每组49例,观察组采用苯磺酸左旋氨氯地平联合贝那普利治疗,对照组仅采用苯磺酸左旋氨氯地平治疗,比较两组的临床疗效及收缩压、舒张压、左室后壁厚度(LVPW)、左室舒张末期室间隔厚度(IVST)、左室舒张末期内径(LVEDD)、左室质量指数(LVMI)的差异.结果 观察组总有效率为93.9％(46/49),显著高于对照组的77.6％( 38/49),差异有统计学意义(x2=5.333,P＜0.05).两组治疗前收缩压及舒张压水平比较差异无统计学意义(P＞0.05).治疗后两组收缩压及舒张压均较治疗前显著下降(P＜0.05)；并且观察组治疗后收缩压及舒张压水平显著低于同期对照组[(121.27±8.69) mm Hg(1 mm Hg=0.133kPa)比(131.54±9.85) mm Hg,(82.45±4.69) mm Hg比(88.49±5.14) mm Hg](P＜ 0.05).两组治疗前LVPW、IVST、LVEDD及LVMI水平比较差异无统计学意义(P＞0.05),治疗后两组LVPW、IVST、LVEDD及LVMI均明显下降(P＜0.05),并且观察组治疗后LVPW、IVST、LVEDD及LVMI明显低于同期对照组[(9.42±1.58) mm比(11.41±1.92) mm,(9.56±1.31) mm比(11.38±1.85) mm,(47.86±2.38) mm比(51.46±3.25) mm,(108.16±6.24) g/m2比(119.21±7.68) g/m2](P＜ 0.05).结论 苯磺酸左旋氨氯地平联合贝那普利对原发性高血压并左室肥厚患者进行治疗,能够明显降低血压,改善患者左室肥厚状态,值得临床推广应用.

abstractsObjective To observe the effect of levamlodipine besylate combined with benazepril in treatment of primary hypertension with left ventricular hypertophy.Methods Ninety-eight primary hypertension with left ventricular hypertrophy patients were divided into two groups by random number table.Observation group(49 cases) was treated with levamlodipine besylate combined with benazepril,and control group (49 cases) was only treated with levamlodipine besylate.The clinical effect,the levels of systolic blood pressure (SBP),diastolic blood pressure (DBP),left ventricular posterior wall (LVPW),interventricular septal thickness (IVST),left ventricular end-diastolic dimension (LVEDD) and left ventricular mass index (LVMI) were compared between two groups.Results The total effective rate in observation group was 93.9％ ( 46/49 ),which was significantly higher than that in control group (77.6％,38/49 ) ( x2 =5.333,P ＜0.05).Before treatment,the differences were not statistically significant in the levels of SBP and DBP (P ＞0.05).After treatment,the levels of SBP,DBP,LVPW,IVST,LVEDD and LVMI were significantly decreased in both groups (P＜0.05).Moreover,the levels of SBP,DBP,LVPW,IVST,LVEDD and LVMI in observation group after treatment were significantly lower than those in control group[ ( 121.27 ± 8.69 ) mmHg( 1 mm Hg =0.133 kPa) vs.( 131.54 ± 9.85 ) mm Hg,( 82.45 ± 4.69 ) mm Hg vs.( 88.49 ± 5.14 ) mmHg,(9.42 ± 1.58 ) mm vs.( 11.41 ± 1.92 ) mm,(9.56 ± 1.31 )mm vs.( 11.38 ± 1.85 ) mm,(47.86 ± 2.38 ) mm vs.(51.46 ±3.25) mm,(108.16 ±6.24) g/m2 vs.(119.21 ±7.68) g/m2] (P ＜0.05).Conclusion Levamlodipine besylate combined with benazepril in treatment of primary hypertension with left ventricular hypertrophy can improve the clinical effects and ease left ventricular hypertrophy status,which can be applied in clinic.