摘要目的 探讨Her-2基因表达与腋淋巴结转移数目之间关系及对预后的影响.方法 选择2008年1月至2011年1月收治的351例原发性乳腺癌患者为研究对象,采用免疫组织化学法检测Her-2基因表达,分析其与腋淋巴结转移数目之间关系及对预后的影响.结果 Her-2基因表达-、+、++与腋淋巴结转移数目之间无相关性(x2=3.757,1.650,2.379,P＞0.05);Her-2基因表达+++与腋淋巴结转移数目之间存在相关性(x2=8.681,P＜0.05);Her-2基因表达-、+、++、+++的2年生存率分别为77.01％(201/261),85.00％(34/40),29.17％(7/24),11.54％(3/26),其中Her-2基因表达-～+的2年生存率明显高于Her-2基因表达++～+++者,差异有统计学意义(x2=61.605,P＜0.01);腋淋巴结转移数目为0枚和1～3枚时,Her-2基因表达-～+的2年生存率明显高于Her-2基因表达++～+++者,差异有统计学意义(x2=61.605,14.747,P＜0.05).腋淋巴结转移数目为4～9枚和≥10枚时,Her-2基因表达-～+的2年生存率与Her-2基因表达++～+++者比较差异无统计学意义(x2=3.691,3.482,P＞0.05).结论 Her-2基因表达-、+、++与腋淋巴结转移无相关性,Her-2基因表达-～+的2年生存率高于Her-2基因表达++～+++者,而Her-2基因表达-与Her-2基因表达+在判断预后上无区别;在腋淋巴结转移数目≤3枚时,Her-2基因表达可作为判断预后的重要因素.

abstractsObjective To investigate the relationship between expression of Her-2 gene and the transfer number of axillary lymph node and its influence on prognosis.Methods A total of 351 cases with primary breast cancer from January 2008 to January 2011 were selected.The expression of Her-2 gene was detected by immunohistochemical method,and analyzed the relationship between it and the transfer number of axillary lymph node and its influence on prognosis.Results The expression of Her-2-,+,++ had no correlation with the transfer number of axillary lymph node (x2 =3.757,1.650,2.379,P ＞ 0.05),while the expression of Her-2 +++ had correlation with the transfer number of axillary lymph node (x2 =8.681,P ＜ 0.05).The 2 years survival rates in the expression of Her-2-,+,++,+++ were 77.01％ (201/261),85.00％ (34/40),29.17％(7/24),1 1.54％ (3/26),and which in the expression of Her-2--+ was significantly higher than that in the expression of Her-2 ++-+++ (x2 =61.605,P ＜ 0.01).The transfer number of axillary lymph node was 0 and 1-3,the 2 years survival rate in the expression of Her-2--+ was significantly higher than that in the expression of Her-2 ++-+++,and there was significant difference (x2 =61.605,14.747,P ＜ 0.05).The transfer number of axillary lymph node was 4-9 and ≥ 10,there was no significant difference in the 2 years survival rate between the expression of Her-2--+ and Her-2 ++-+++ (x2 =3.691,3.482,P ＞ 0.05).Conclusions The expression of Her-2-,+,++ has no correlation with axillary lymph node metastasis,and the 2 years survival rate in the expression of Her-2--+ is higher than that in the expression of Her-2 ++-+++,while Her-2-has no difference with Her-2 + in prognosis.While the transfer number of axillary lymph node ≤ 3,the expression of Her-2 gene may be an important prognostic factor.